![](/images/graphics-bg.png)
Yuk-Mi-Jihwang-Tang, a Traditional Korean Multiple Herbal Formulae, Improves Hippocampal Memory on Scopolamine Injection-Induced Amnesia Model of C57BL6 Mice
المؤلفون المشاركون
Lee, Hye Won
Lee, Hye Lim
Kim, Hyeong-Geug
Yoo, Horyong
Lim, Sung-Ah
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We evaluated neuropharmacological properties of Yuk-Mi-Jihwang-Tang (YJT) against scopolamine injection-induced memory impairment mice model.
Mice were orally administered with YJT (50, 100, or 200 mg/kg) or tacrine (TAC, 12.5 mg/kg) for 10 days.
At the first day of Morris water maze task, scopolamine (2 mg/kg) was intraperitoneally injected before 30 min of it.
The hippocampal memory function was determined by the Morris water maze task for 5 days consecutively.
Scopolamine drastically increased escape latency and decreased time spent in target quadrant.
Pretreatment YJT properly improved them.
Regarding the redox status, YJT significantly reduced the oxidative stress and it also exerted much effort to improve both superoxide dismutase and catalase activities in hippocampal gene expression and protein levels.
These effects were well coincided with immunohistochemical analysis of 4-hydroxyneal-positive signals in hippocampal areas.
Additionally, acetylcholine esterase activities and brain-derived neurotrophic factor abnormalities in the hippocampal protein levels were significantly normalized by YJT, and their related molecules were also improved.
The neuronal proliferation in hippocampal regions was markedly inhibited by scopolamine, whereas YJT notably recovered them.
Collectively, YJT exerts much effort to enhance memorial functions through improving redox status homeostasis and partially regulates acetylcholine esterase activities as well as neuronal cell proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Hye Lim& Lim, Sung-Ah& Lee, Hye Won& Yoo, Horyong& Kim, Hyeong-Geug. 2018. Yuk-Mi-Jihwang-Tang, a Traditional Korean Multiple Herbal Formulae, Improves Hippocampal Memory on Scopolamine Injection-Induced Amnesia Model of C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154683
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Hye Lim…[et al.]. Yuk-Mi-Jihwang-Tang, a Traditional Korean Multiple Herbal Formulae, Improves Hippocampal Memory on Scopolamine Injection-Induced Amnesia Model of C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154683
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Hye Lim& Lim, Sung-Ah& Lee, Hye Won& Yoo, Horyong& Kim, Hyeong-Geug. Yuk-Mi-Jihwang-Tang, a Traditional Korean Multiple Herbal Formulae, Improves Hippocampal Memory on Scopolamine Injection-Induced Amnesia Model of C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154683
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154683
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)