Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia
المؤلفون المشاركون
Mothana, R. A. A.
Al-Ajmi, Mohamed F.
Al-Rehaily, Adnan J.
Khaled, Jamal M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Tuberculosis (TB) remains a common deadly infectious disease and worldwide a major health problem.
The current study was therefore designed to investigate the in vitro antimycobacterial activity of different extracts of Alpinia galanga and Tinospora cordifolia.
Moreover, a safety assessment for both plants was carried out.
Dichloromethane and ethanolic extracts of each plant were examined against H37Rv INH-sensitive and resistant INH strains of Mycobacterium tuberculosis.
The safety assessment of both plants has been performed through in vivo acute and chronic toxicity studies in animal model.
Body weight, food consumption, water intake, organ’s weight, and haematological and biochemical parameters of blood and serum were evaluated.
The extracts of A.
galanga and T.
cordifolia produced significant and dose-dependent inhibitory activity with maximum effect of 18-32% at 50 μg/ml against both strains of M.
tuberculosis.
No effect on the body weight or food and water consumption was observed but A.
galanga caused significantly an increase in the relative weight of the heart, liver, spleen, and kidney.
Haematological studies of both plants revealed a slight but significant fall in the RBC and WBC level as well as haemoglobin and platelets.
In addition, A.
galanga extracts increased significantly liver enzymes and bilirubin and glucose.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Ajmi, Mohamed F.& Mothana, R. A. A.& Al-Rehaily, Adnan J.& Khaled, Jamal M.. 2018. Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154713
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Ajmi, Mohamed F.…[et al.]. Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154713
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Ajmi, Mohamed F.& Mothana, R. A. A.& Al-Rehaily, Adnan J.& Khaled, Jamal M.. Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154713
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154713
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر