Effect of Xuefu Zhuyu Decoction Pretreatment on Myocardium in Sepsis Rats
المؤلفون المشاركون
Cai, Yu
Meng, Fansu
Lai, Haibiao
Luo, Zekun
Liu, Yong
Huang, Xiaoxun
Chen, Junqian
Liu, Bayi
Guo, Yingjun
Huang, Qingqing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Xuefu Zhuyu Decoction (XFZYD), the classical recipe for promoting blood circulation by removing blood stasis, has been used in China for a long history clinically.
XFZYD has been found to improve cardiac function through reducing inflammation.
However, the effect of XFZYD on myocardial apoptosis remains unclear.
Herein, we investigated the mechanism of XFZYD preconditioning on myocardial injury in sepsis rats.
The rats were treated with XFZYD one week, followed with intraperitoneal injection of lipopolysaccharide (LPS: 10 mg/kg) to induce sepsis.
Pretreatment with XFZYD could reverse the effects of LPS-induced decreased mean arterial pressure (MAP) and increased heart rate (HR).
XFZYD decreased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in serum or in heart.
TUNEL staining revealed that the apoptotic index of XFZYD was significantly lower compared with the LPS group (P<0.05).
Western blot results showed that the high doses of pretreatment XFZYD group can reduce the Bax expression of myocardial tissue in rats (P<0.05, P<0.01).
The expression of Bcl-2 in XFZYD group was significantly higher than that in the LPS group (P<0.01), while the expression of caspase-3 in treatment group was significantly lower than that in the LPS group only after 12 h modeling (P<0.01).
In addition, caspase-3 activity in rat cardiomyocytes of XFZYD-treated animals was significantly decreased.
These findings suggest that pretreatment with XFZYD exerts a protective effect in the myocardium of septic rats by inhibiting myocardial cell apoptosis and antioxidation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Fansu& Lai, Haibiao& Luo, Zekun& Liu, Yong& Huang, Xiaoxun& Chen, Junqian…[et al.]. 2018. Effect of Xuefu Zhuyu Decoction Pretreatment on Myocardium in Sepsis Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154714
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Fansu…[et al.]. Effect of Xuefu Zhuyu Decoction Pretreatment on Myocardium in Sepsis Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154714
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Fansu& Lai, Haibiao& Luo, Zekun& Liu, Yong& Huang, Xiaoxun& Chen, Junqian…[et al.]. Effect of Xuefu Zhuyu Decoction Pretreatment on Myocardium in Sepsis Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154714
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154714
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر