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Chinese Herbal Injections for Primary Nephrotic Syndrome in Adults: A Systematic Review and Network Meta-Analysis
المؤلفون المشاركون
Han, Shisheng
Yao, Tianwen
Lu, Yanhua
Lu, Yan
Xu, Yanqiu
Wang, Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Primary nephrotic syndrome (PNS) is a common renal disease that presents with heavy proteinuria and hypoalbuminemia.
Despite notable advances in its treatment, some patients show poor responses and clinical outcomes when treated with conventional Western medicine (WM).
Chinese herbal injections (CHIs) have been reported to have beneficial effects for PNS.
The aim of the present study was to comprehensively determine the efficacy and safety of CHIs for PNS in adults using a network meta-analysis approach.
PubMed, Embase, the Cochrane library, and four Chinese databases were systematically searched to identify randomized controlled trials (RCTs) using CHIs for treatment of PNS published before June 1, 2019.
Quality assessment of the identified RCTs was performed according to the Cochrane Handbook.
Pooled odds ratios (OR) or mean differences (MD) with corresponding 95% confidence intervals (CI) were calculated for discrete or continuous variables, respectively.
The primary outcome was complete/total remission and secondary outcomes were serum albumin and urinary protein excretion.
The surface under the cumulative ranking curve (SUCRA) value and cluster analyses were used to rank treatment by probability.
Eighty-five studies involving 11 CHIs and 5801 subjects were included.
Compared with WM alone, CHI plus WM showed an improved complete/total remission rate as well as higher serum albumin and lower 24-hour urinary protein excretion, except in the following: Yinxingye injection plus WM did not improve the total remission rate, and Dengzhanhua or Xueshuantong injection plus WM did not lower the 24-hour urinary protein excretion.
Either Danhong (DH) or Dengzhanhua (DZH) injection plus WM was the preferable treatment for PNS based on SUCRA and cluster analyses of clinical remission and adverse events.
However, considering that literature in this area is limited, these results need further validation.
CHIs administered as adjuvants to WM showed favourable outcomes for PNS.
DH + WM and DZH + WM might be the potential optimal therapies for PNS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Shisheng& Yao, Tianwen& Lu, Yanhua& Lu, Yan& Xu, Yanqiu& Wang, Yi. 2020. Chinese Herbal Injections for Primary Nephrotic Syndrome in Adults: A Systematic Review and Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154727
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Shisheng…[et al.]. Chinese Herbal Injections for Primary Nephrotic Syndrome in Adults: A Systematic Review and Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1154727
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Shisheng& Yao, Tianwen& Lu, Yanhua& Lu, Yan& Xu, Yanqiu& Wang, Yi. Chinese Herbal Injections for Primary Nephrotic Syndrome in Adults: A Systematic Review and Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154727
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154727
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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