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Pharmacological Network Reveals the Active Mechanism of Qi-Replenishing, Spleen-Strengthening, Phlegm-Dispelling, and Blood-Nourishing Fufang on Coronary Heart Disease
المؤلفون المشاركون
Wang, Jianan
Zheng, Sicheng
Dang, Boyi
Zhang, Zhe
Liu, Yue
Zhang, Fan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study aimed to investigate the potential targets and pathways of qi-replenishing, spleen-strengthening, phlegm-dispelling, and blood-nourishing Fufang in the treatment of coronary heart disease (CHD).
The composition of Fufang was identified, followed by screening of the active components using ADME.
The targets of active components were predicted and screened based on the TCMSP and BATMAN databases and were cross-validated using the CTD database and DisGeNET.
A functional enrichment analysis was performed using the ClueGO + CluePedia plugins and clusterProfiler in the R package.
The protein-protein interaction (PPI) network was constructed using the STRING database and Cytoscape.
Finally, a pharmacological network was constructed.
A total of 27 overlapping targets were obtained after cross-validation.
ALB, IL-6, and TNF were the hub genes in the PPI network.
The pharmacological network included 59 nodes and 189 relation pairs.
Among the 59 nodes, there were 2 herbal medicine nodes (Salvia miltiorrhiza and Astragalus mongholicus), 8 chemical component nodes (magnesium lithospermate B, neocryptotanshinone II, heteratisine, daphneolone, tanshinone IIA, tanshinone IIB, soyasapogenol B, and astragaloside II), 27 target protein nodes (such as ALB, TNF, IL-6, NFKB1, APOA1, APOA2, CYP1A1, and CYP1A2), and 22 pathway nodes (such as the toll-like receptor signaling pathway, IL-17 signaling pathway, and TNF signaling pathway).
Therefore, we found that the genes TNF, IL-6, NFKB1, ALB, CYP1A1, CYP1A2, APOA1, and APOA2 might be important targets of the key active compounds neocryptotanshinone II and astragaloside II.
These genes targeted by the key active compounds might regulate inflammation-related pathways and the level of albumin and cholesterol in CHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Fan& Liu, Yue& Zheng, Sicheng& Dang, Boyi& Wang, Jianan& Zhang, Zhe. 2020. Pharmacological Network Reveals the Active Mechanism of Qi-Replenishing, Spleen-Strengthening, Phlegm-Dispelling, and Blood-Nourishing Fufang on Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154733
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Fan…[et al.]. Pharmacological Network Reveals the Active Mechanism of Qi-Replenishing, Spleen-Strengthening, Phlegm-Dispelling, and Blood-Nourishing Fufang on Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154733
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Fan& Liu, Yue& Zheng, Sicheng& Dang, Boyi& Wang, Jianan& Zhang, Zhe. Pharmacological Network Reveals the Active Mechanism of Qi-Replenishing, Spleen-Strengthening, Phlegm-Dispelling, and Blood-Nourishing Fufang on Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154733
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154733
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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