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Pineapple Vinegar Regulates Obesity-Related Genes and Alters the Gut Microbiota in High-Fat Diet (HFD) C57BL6 Obese Mice
المؤلفون المشاركون
Alitheen, Noorjahan Banu
Mohamad, Nurul Elyani
Yeap, Swee Keong
Ky, Huynh
Liew, Nancy Woan Charn
Beh, Boon Kee
Boo, Sook Yee
Ho, Wan Yong
Sharifuddin, Shaiful Adzni
Long, Kamariah
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Obesity is a pandemic metabolic syndrome with increasing incidences every year.
Among the significant factors that lead to obesity, overconsumption of high-fat food in daily intake is always the main contributor.
Functional foods have shown a positive effect on disease prevention and provide health benefits, including counteracting obesity problem.
Vinegar is one of the fermented functional beverages that have been consumed for many years, and different types of vinegar showed different bioactivities and efficacies.
In this study, we investigated the potential effects of pineapple vinegar as an antiobesity agent on a high-fat diet- (HFD-) induced C57BL/6 obese mice.
C57BL/6 mice were treated with pineapple vinegar (1 mL/kg BW and 0.08 mL/kg BW) for 12 weeks after 24 weeks of HFD incubation.
Serum biochemistry profiles, antioxidant assays, qPCR, proteome profiler, and 16S metagenomic were done posttreatment.
Our data showed that a high concentration of pineapple vinegar (1 mL/kg BW) treatment significantly (p<0.05) reduced the bodyweight (∼20%), restored lipid profiles, increased the antioxidant activities, and reduced the oxidative stress.
Besides, significant (p<0.05) regulation of several adipokines and inflammatory-related genes was recorded.
Through the regulation of gut microbiota, we found a higher abundance of Akkermansia muciniphila, a microbiota reported to be associated with obesity in the high concentration of pineapple vinegar treatment.
Collectively, these data established the mechanism of pineapple vinegar as antiobesity in mice and revealed the potential of pineapple vinegar as a functional food for obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohamad, Nurul Elyani& Yeap, Swee Keong& Ky, Huynh& Liew, Nancy Woan Charn& Beh, Boon Kee& Boo, Sook Yee…[et al.]. 2020. Pineapple Vinegar Regulates Obesity-Related Genes and Alters the Gut Microbiota in High-Fat Diet (HFD) C57BL6 Obese Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154756
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohamad, Nurul Elyani…[et al.]. Pineapple Vinegar Regulates Obesity-Related Genes and Alters the Gut Microbiota in High-Fat Diet (HFD) C57BL6 Obese Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1154756
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohamad, Nurul Elyani& Yeap, Swee Keong& Ky, Huynh& Liew, Nancy Woan Charn& Beh, Boon Kee& Boo, Sook Yee…[et al.]. Pineapple Vinegar Regulates Obesity-Related Genes and Alters the Gut Microbiota in High-Fat Diet (HFD) C57BL6 Obese Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154756
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154756
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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