Gengnianchun, a Traditional Chinese Medicine, Enhances Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating daf-16FOXO
المؤلفون المشاركون
Meng, Fanhui
Li, Jun
Wang, Wenjun
Fu, Yan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Gengnianchun (GNC), a traditional Chinese medicine (TCM), is primarily used to improve declining functions related to aging.
In this study, we investigated its prolongevity and stress resistance properties and explored the associated regulatory mechanism using a Caenorhabditis elegans model.
Methods.
Wild-type C.
elegans N2 was used for lifespan analysis and oxidative stress resistance assays.
Transgenic animals were used to investigate pathways associated with antioxidative stress activity.
The effects of GNC on levels of reactive oxygen species (ROS) and expression of specific genes were examined.
Results.
GNC-treated wild-type worms showed an increase in survival time under both normal and oxidative stress conditions.
GNC decreased intracellular ROS levels by 67.95%.
GNC significantly enhanced the oxidative stress resistance of several mutant strains, suggesting that the protective effect of GNC is independent of the function of these genes.
However, the oxidative stress resistance effect of GNC was absent in worms with daf-16 mutation.
We also found upregulation of daf-16 downstream targets including sod-3 and mtl-1.
Conclusions.
Our findings suggest that GNC extends the lifespan of C.
elegans and enhances its resistance to oxidative stress via a daf-16/FOXO-dependent pathway.
This study also provides a feasible method for screening the biological mechanisms of TCMs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Fanhui& Li, Jun& Wang, Wenjun& Fu, Yan. 2017. Gengnianchun, a Traditional Chinese Medicine, Enhances Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating daf-16FOXO. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Fanhui…[et al.]. Gengnianchun, a Traditional Chinese Medicine, Enhances Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating daf-16FOXO. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Fanhui& Li, Jun& Wang, Wenjun& Fu, Yan. Gengnianchun, a Traditional Chinese Medicine, Enhances Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating daf-16FOXO. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر