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Antileishmanial and Immunomodulatory Effect of Babassu-Loaded PLGA Microparticles: A Useful Drug Target to Leishmania amazonensis Infection
المؤلفون المشاركون
Nicolete, Roberto
Nascimento, F. R. F.
da Silva, Mayara Cristina Pinto
Guerra, Rosane Nassar Meireles
Silva, Lucilene Amorim
Azevedo-Santos, Ana Paula S.
Brito, Jefferson Mesquita
Ferreira, Amalia dos Santos
Vale, Andre Alvares Marques
Pereira, Paulo Vitor Soeiro
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-25
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The immunological and the anti-Leishmania amazonensis activity of babassu-loaded poly(lactic-co-glycolic acid) [PLGA] microparticles was evaluated.
The anti-Leishmania activity was evaluated against promastigotes or amastigotes forms, in Balb/c macrophages.
The size of the microparticles ranged from 3 to 6.4 μm, with a zeta potential of −25 mV and encapsulation efficiency of 48%.
The anti-Leishmania activity of the PLGA microparticles loaded with the aqueous extract of babassu mesocarp (MMP) (IC50) was 10-fold higher than that free extract (Meso).
MMP exhibited overall bioavailability and was very effective in eliminating intracellular parasites.
MMP also reduced ex vivo parasite infectivity probably by the increased production of nitric oxide, hydrogen peroxide, and TNF-α indicating the activation of M1 macrophages.
The overexpression of TNF-α did not impair cell viability, suggesting antiapoptotic effects of MMP.
In conclusion, babassu-loaded microparticles could be useful for drug targeting in the treatment of leishmaniasis, due to the immunomodulatory effect on macrophage polarization and the increased efficacy as an anti-Leishmania product after the microencapsulation.
These findings are of great relevance since the development of new drugs for the treatment of neglected diseases is desirable, mainly if we consider the high morbidity and mortality rates of leishmaniasis worldwide.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
da Silva, Mayara Cristina Pinto& Brito, Jefferson Mesquita& Ferreira, Amalia dos Santos& Vale, Andre Alvares Marques& Azevedo-Santos, Ana Paula S.& Silva, Lucilene Amorim…[et al.]. 2018. Antileishmanial and Immunomodulatory Effect of Babassu-Loaded PLGA Microparticles: A Useful Drug Target to Leishmania amazonensis Infection. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1154784
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
da Silva, Mayara Cristina Pinto…[et al.]. Antileishmanial and Immunomodulatory Effect of Babassu-Loaded PLGA Microparticles: A Useful Drug Target to Leishmania amazonensis Infection. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1154784
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
da Silva, Mayara Cristina Pinto& Brito, Jefferson Mesquita& Ferreira, Amalia dos Santos& Vale, Andre Alvares Marques& Azevedo-Santos, Ana Paula S.& Silva, Lucilene Amorim…[et al.]. Antileishmanial and Immunomodulatory Effect of Babassu-Loaded PLGA Microparticles: A Useful Drug Target to Leishmania amazonensis Infection. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1154784
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154784
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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