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The Root Aqueous Extract of Entada africana Guill. et Perr. (Mimosaceae) Inhibits Implant Growth, Alleviates Dysmenorrhea, and Restores Ovarian Dynamic in a Rat Model of Endometriosis
المؤلفون المشاركون
Njamen, Dieudonné
Ateba, Sylvin Benjamin
Mvondo, Marie Alfrede
Minko Essono, Stéphane
Bomba Tatsinkou, Francis Désiré
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Entada africana (Mimosaceae) was reported to have analgesic and antioxidant properties.
The present study is aimed at investigating the effects of the root aqueous extract of Entada africana (EA) on an experimental model of endometriosis.
The study was performed in rats orally treated with EA at doses of 127.5, 255, and 510 mg/kg.
Microgynon® 30 served as the reference substance.
Estradiol valerate and oxytocin were used to induce dysmenorrhea.
Endometrial implant levels of catalase and malondialdehyde (MDA) allowed estimating tissue oxidative status.
Ovarian dynamic and rat sexual behavior were assessed through histological analysis of ovaries, uterus, and vagina.
EA decreased dysmenorrhea at tested doses following a 7-day treatment (p<0.001).
Endometrial implant volume decreased following the three treatment periods (p<0.05).
Catalase activity (p<0.001) and MDA level (p<0.01) increased only following a 3-day treatment.
EA also increased antral follicles, reduced luteinized unruptured follicle number (p<0.001), and induced animals to be in the estrus phase.
In conclusion, EA prevented the progress of endometriosis, reduced dysmenorrhea, promoted ovarian follicle growth, prevented anovulation, and stimulated the special period of rat sexual desire.
These results suggest that Entada africana could be a promising alternative option for the treatment of endometriosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mvondo, Marie Alfrede& Minko Essono, Stéphane& Bomba Tatsinkou, Francis Désiré& Ateba, Sylvin Benjamin& Njamen, Dieudonné. 2017. The Root Aqueous Extract of Entada africana Guill. et Perr. (Mimosaceae) Inhibits Implant Growth, Alleviates Dysmenorrhea, and Restores Ovarian Dynamic in a Rat Model of Endometriosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154799
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mvondo, Marie Alfrede…[et al.]. The Root Aqueous Extract of Entada africana Guill. et Perr. (Mimosaceae) Inhibits Implant Growth, Alleviates Dysmenorrhea, and Restores Ovarian Dynamic in a Rat Model of Endometriosis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1154799
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mvondo, Marie Alfrede& Minko Essono, Stéphane& Bomba Tatsinkou, Francis Désiré& Ateba, Sylvin Benjamin& Njamen, Dieudonné. The Root Aqueous Extract of Entada africana Guill. et Perr. (Mimosaceae) Inhibits Implant Growth, Alleviates Dysmenorrhea, and Restores Ovarian Dynamic in a Rat Model of Endometriosis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154799
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154799
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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