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Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1Smad Signaling Pathway
المؤلفون المشاركون
Yuan, Xingxing
Gong, Zhiqiang
Wang, Bingyu
Guo, Xueying
Yang, Lei
Li, Dandan
Zhang, Yali
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Activation of HSC is a pivotal step in hepatic fibrosis.
In the activation of HSC, the TGF-β1 plays a key role that can promote the occurrence of hepatic fibrosis by combining with Smad proteins.
Astragaloside is the main active component extracted from Radix Astragali that has the effect of antioxidation and hepatoprotection.
In the present study, we investigated the mechanism of astragalosides inhibiting hepatic fibrosis in vitro and in vivo.
In vitro, astragalosides inhibited the activation of HSC and regulated the expression of MMP-2 and TIMP-2 and reduced the formation of collagen fibers.
In vivo, administration of astragalosides decreased the serum ALT, AST, and TBiL in rats by reducing oxidative stress.
Astragalosides also attenuated hepatic fibrosis by reducing the concentration of hydroxyproline and inhibiting the formation of collagen fibers.
The expressions of TGF-β1, TβR-I, p-Smad 2, and p-Smad 3 were downregulated after astragalosides treatments, while Smad 7 was upregulated compared to the control group.
The results indicated that the effect of astragaloside on hepatic fibrosis was related to the inhibition of HSC activation and the modulation of the TGF-β1/Smad signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Xingxing& Gong, Zhiqiang& Wang, Bingyu& Guo, Xueying& Yang, Lei& Li, Dandan…[et al.]. 2018. Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1Smad Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1154806
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Xingxing…[et al.]. Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1Smad Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1154806
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Xingxing& Gong, Zhiqiang& Wang, Bingyu& Guo, Xueying& Yang, Lei& Li, Dandan…[et al.]. Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1Smad Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1154806
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154806
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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