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Effect of Kangshuanyihao Formula on the Inflammatory Reaction and SIRT1TLR4NF-κB Signaling Pathway in Endothelial Injury
المؤلفون المشاركون
Han, Jie
Tong, Hua-Qin
Cheng, Song-Yi
Yang, Li
Chen, Han-Yu
Chen, Jian-Dong
Chen, Xiao-Hu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Endothelial injury plays an important role in atherosclerosis (AS).
Kangshuanyihao formula uses therapeutic principles from Chinese medicine to supplement Qi, thereby promoting blood circulation, and remove blood stasis.
The mechanism by which the formula inhibits endothelial injury was examined in a rat model of 1,25-dihydroxyvitamin D3 (VD3) intraperitoneal injection and high-fat-induced endothelial injury.
Rats were randomly divided into the model, high-dose, middle-dose, low-dose, positive drug (rosuvastatin), and combination (positive drug + middle-dose) groups; 10 Sprague-Dawley rats served as the blank group.
The aortic endothelium was stained with hematoxylin and eosin and the levels of blood lipids and inflammation markers (mRNA and protein) were measured.
Endothelial injury, lipid levels, and inflammation were increased in the model.
Kangshuanyihao formula reduced endothelial injury, improved lipid levels, and downregulated inflammation, as shown by significant reduction of the protein levels of SIRT1, TLR4, and NF-κB and mRNA levels of SIRT1, TLR4, NF-κB, IL-1β, IL-6, and IL-12.
Thus, we conclude that Kangshuanyihao formula can inhibit the inflammatory reaction in the rat model of high-fat-induced endothelial injury after intraperitoneal injection of VD3.
This mechanism may be attributed to regulating the SIRT1/TLR4/NF-κB signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Jie& Tong, Hua-Qin& Cheng, Song-Yi& Yang, Li& Chen, Han-Yu& Chen, Jian-Dong…[et al.]. 2017. Effect of Kangshuanyihao Formula on the Inflammatory Reaction and SIRT1TLR4NF-κB Signaling Pathway in Endothelial Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Jie…[et al.]. Effect of Kangshuanyihao Formula on the Inflammatory Reaction and SIRT1TLR4NF-κB Signaling Pathway in Endothelial Injury. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Jie& Tong, Hua-Qin& Cheng, Song-Yi& Yang, Li& Chen, Han-Yu& Chen, Jian-Dong…[et al.]. Effect of Kangshuanyihao Formula on the Inflammatory Reaction and SIRT1TLR4NF-κB Signaling Pathway in Endothelial Injury. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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