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Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats
المؤلفون المشاركون
Ullah, Riaz
Shahat, Abdelaaty A.
Alqahtani, Ali S.
Husseiny, Husseiny A.
Al Meanazel, Osaid T. R.
al-Said, Mansour
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Eriobotrya japonica is traditionally used as an antipyretic, digestive, and diuretic agent.
Its flowers possess free radical–scavenging, antioxidative, and hepatoprotective effects.
We investigated the hepatoprotective potential of E.
japonica leaf extract and its various fractions against hepatotoxicity in rats.
Liver injury was stimulated by the oral administration of carbon tetrachloride (CCl4; 2.5 mL/kg b.wt.).
Male albino rats (n = 55) were distributed arbitrarily into 11 groups: Group I, normal control group; Group II, CCl4 (positive control group); Group III, CCl4 + silymarin; Groups IV and V, CCl4 + two doses of 250 and 500 mg/kg of the 80% methanolic extract of E.
japonica leaves, respectively; Groups VI and VII, CCl4 + 250 mg/kg and 500 mg/kg of the ethyl acetate fraction, respectively; Groups VIII and IX, CCl4 + 250 and 500 mg/kg of the butanol fraction, respectively; and Groups X and XI, CCl4 + 250 and 500 mg/kg of the aqueous fraction of E.
Japonica leaves, respectively.
CCl4-treated rats that were given 250 or 500 mg/kg of the methanol extract of E.
Japonica leaves, or its ethyl acetate, butanol, or aqueous fractions, had significantly lower levels of biochemical parameters such as alanine aminotransferase, aspartate transaminase, alkaline phosphate, total protein, gamma-glutamyl transferase, and bilirubin levels than those of the CCl4 positive group.
However, the extract and fractions did not significantly affect lipid profiles.
Thus, we conclude that Eriobotrya leaf extract and its fractions have a hepatoprotective effect against CCl4-induced hepatotoxicity in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shahat, Abdelaaty A.& Ullah, Riaz& Alqahtani, Ali S.& al-Said, Mansour& Husseiny, Husseiny A.& Al Meanazel, Osaid T. R.. 2018. Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shahat, Abdelaaty A.…[et al.]. Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shahat, Abdelaaty A.& Ullah, Riaz& Alqahtani, Ali S.& al-Said, Mansour& Husseiny, Husseiny A.& Al Meanazel, Osaid T. R.. Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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