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Astilbe chinensis Modulates Platelet Function via Impaired MAPK and PLCγ2 Expression
المؤلفون المشاركون
Lee, Seung Eun
Irfan, Muhammad
Jeon, Bo-Ra
Lee, Jeong Hoon
Rhee, Man Hee
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Platelets play major role in maintaining hemostasis while hyperactivation of platelets may lead to arterial thrombosis.
Natural products and ethnomedicine have been shown to reduce the risk of cardiovascular diseases (CVDs).
Astilbe chinensis is a perennial herb found in China, Korea, Russia, and Japan, which is also known for its medicinal effects, and has been used in Korean traditional medicine to treat inflammation, cancer, chronic bronchitis, and headache.
We hypothesized that given herbal plant exhibits pharmacological activities against CVDs, and we specifically explored their effects on platelet function.
Methodology.
Platelet aggregation was evaluated using standard light-transmission aggregometry.
Intracellular calcium mobilization was assessed using Fura-2/AM, and granule secretion (ATP release) was measured in a luminometer.
Fibrinogen binding to integrin αIIbβ3 was assessed using flow cytometry.
Phosphorylation of mitogen-activated protein kinase (MAPK) signaling molecules and activation of the phosphoinositide 3-kinase (PI3K)/Akt were assessed using western blots, and further, glycoprotein VI (GPVI) signaling components were studied using immunoprecipitation.
Key Results.
A.
chinensis extracts potently and significantly inhibited platelet aggregation, calcium mobilization, granule secretion, and fibrinogen binding to integrin αIIbβ3.
Moreover, it significantly inhibited MAPK phosphorylation and expression of GPVI downstream signaling molecules.
Conclusion.
A.
chinensis extract inhibited platelet aggregation and granule secretion and attenuated GPVI downstream signaling, indicating the potential therapeutic effects of this plant extract on the cardiovascular system and platelet function.
We suggest that given plant extract may be a potent candidate to treat platelet-related CVDs and to be used as antiplatelet agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jeon, Bo-Ra& Irfan, Muhammad& Lee, Seung Eun& Lee, Jeong Hoon& Rhee, Man Hee. 2018. Astilbe chinensis Modulates Platelet Function via Impaired MAPK and PLCγ2 Expression. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154984
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jeon, Bo-Ra…[et al.]. Astilbe chinensis Modulates Platelet Function via Impaired MAPK and PLCγ2 Expression. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154984
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jeon, Bo-Ra& Irfan, Muhammad& Lee, Seung Eun& Lee, Jeong Hoon& Rhee, Man Hee. Astilbe chinensis Modulates Platelet Function via Impaired MAPK and PLCγ2 Expression. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154984
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154984
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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