Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKTGSK3 ββ-Catenin Pathway by Restoring Autophagic Activity
المؤلفون المشاركون
Gao, Yanbin
Wang, Xiaolei
Shi, Yimin
Wang, Tao
He, Jiaxin
Xu, Jiayi
Wu, Bingjie
Li, Yimeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Diabetic nephropathy (DN), a complication of diabetes, is the result of high glucose-induced pathological changes in podocytes, such as epithelial-mesenchymal transition (EMT).
Autophagy is an important mechanism of podocyte repair.
Ginsenoside Rg1, the active ingredient of ginseng extract, has antifibrotic and proautophagic effects.
Therefore, we hypothesized that ginsenoside Rg1 can reverse podocyte EMT via autophagy and alleviate DN.
Aim.
This study aimed to investigate the effect of ginsenoside Rg1 on DN rats and high glucose-induced podocyte EMT by regulating the AKT/GSK3β/β-catenin pathway by restoring autophagy activity.
Methods.
Diabetic rats induced by STZ injection were treated with 50 mg/kg ginsenoside Rg1 for 8 weeks, and the renal functional, metabolic, and histopathological indices were evaluated.
DN was simulated in vitro by exposing podocytes to high glucose levels and treated with ginsenoside Rg1.
The expression of EMT and autophagy-related markers was analyzed in vivo and in vitro by immunofluorescence, western blotting, and real-time PCR.
Results.
Ginsenoside Rg1 significantly alleviated renal fibrosis and podocyte EMT in diabetic rats, and podocytes exposed to high glucose levels, which was abolished by the autophagy inhibitor 3-MA.
Furthermore, ginsenoside Rg1 regulated the AKT/GSK3 β/β-catenin pathway by restoring autophagic activity.
Conclusion.
Ginsenoside Rg1 alleviated podocyte EMT by enhancing AKT/GSK3β/β-catenin pathway-mediated autophagy, indicating its therapeutic potential for DN and other glomerular diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Yimin& Gao, Yanbin& Wang, Tao& Wang, Xiaolei& He, Jiaxin& Xu, Jiayi…[et al.]. 2020. Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKTGSK3 ββ-Catenin Pathway by Restoring Autophagic Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Yimin…[et al.]. Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKTGSK3 ββ-Catenin Pathway by Restoring Autophagic Activity. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1154999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Yimin& Gao, Yanbin& Wang, Tao& Wang, Xiaolei& He, Jiaxin& Xu, Jiayi…[et al.]. Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKTGSK3 ββ-Catenin Pathway by Restoring Autophagic Activity. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر