Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract
المؤلفون المشاركون
Park, Seung-Chun
Park, Ji-Yong
Lee, Seung-Jin
Park, Na-Hye
Birhanu, Biruk Tesfaye
Mechesso, Abraham Fikru
Park, Eun-Jin
Lee, Sam-Pin
Youn, Sun-Joo
Hossain, Md. Akil
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate the potentials of fermented Cucurbita moschata extract (FCME) in the treatment of obesity and nonalcoholic fatty liver disease (NAFLD).
Five-week-old male C57BL/6 mice were assigned to 6 groups and treated for 8 weeks by feeding the normal diet (ND) and high fat diet (HFD) with and without FCME.
Changes in body weight gain and consumption of feed and water were recorded.
Major organs, adipose tissues, and blood samples were collected after the experimental period.
The serum lipid profile, histological features of liver and adipose tissues, and mRNA expression of different adipogenic/lipogenic genes from liver tissue were evaluated.
The supplementation of FCME in HFD significantly prevented HFD-induced increment of bodyweight.
The adipose tissue mass, liver enzymes, and plasma lipids were also reduced significantly ( p < 0.05 ) by the consumption of FCME.
The mRNA expressions of adipogenic/lipogenic genes (PPARγ, C/EBPα, C/EBP β, C/EBPγ, and SREBP-1C) in FCME-treated obese mice were considerably ( p < 0.05 ) suppressed.
FCME showed its antiobesity potential by suppressing the body weight gain and by modulating the plasma lipids and liver enzymes through the regulation of adipogenic/lipogenic transcriptional factors.
Fermented Cucurbita moschata could be an opportunistic agent in controlling obesity and fatty liver changes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hossain, Md. Akil& Lee, Seung-Jin& Park, Na-Hye& Birhanu, Biruk Tesfaye& Mechesso, Abraham Fikru& Park, Ji-Yong…[et al.]. 2018. Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hossain, Md. Akil…[et al.]. Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hossain, Md. Akil& Lee, Seung-Jin& Park, Na-Hye& Birhanu, Biruk Tesfaye& Mechesso, Abraham Fikru& Park, Ji-Yong…[et al.]. Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر