Effects and Mechanism of Huannao Yicong Decoction Extract on the Ethology of Transgenic APPPS1 Mice
المؤلفون المشاركون
Liu, Jiangang
Liu, Meixia
Liu, Longtao
Wei, Yun
Li, Hao
Yang, Yang
Liang, Lin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
To investigate the mechanism of Huannao Yicong Decoction (HYD) extract on improving of learning memory of transgenic amyloid precursor protein (APP)/presenilin 1 (PS1) mice, we randomly divided 60 transgenic APP/PS1 mice of 3 months old into 4 groups: the model group, the Donepezil group, the HYD-L group, and the HYD-H group, with 15 C57BL/6J mice of the same genetic background as the control group.
These mice were gavaged for 6 months in a row.
The results showed that the latency was significantly shortened and the number of passing through the original platform was increased.
HYD extract can increase the amount of neurons and improve the morphological structure of Nissl body obviously.
The γ-secretase activity and the expression of phosphorylated APP, Aβ1-40, and Aβ1-42 in hippocampal CA1 were significantly decreased.
The expressions of protein and mRNA of PEN-2 and CREB in hippocampal were significantly downregulated.
These results demonstrated that HYD extract can improve the memory ability of transgenic APP/PS1 mice, which was related to the protection of neurons and structure of Nissl body, reducing cleavage of APP and production of Aβ and inhibiting the activity of γ-secretase by decreasing CREB activity because of downregulated expression of PEN-2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Meixia& Wei, Yun& Yang, Yang& Liu, Longtao& Liang, Lin& Liu, Jiangang…[et al.]. 2017. Effects and Mechanism of Huannao Yicong Decoction Extract on the Ethology of Transgenic APPPS1 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1155019
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Meixia…[et al.]. Effects and Mechanism of Huannao Yicong Decoction Extract on the Ethology of Transgenic APPPS1 Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1155019
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Meixia& Wei, Yun& Yang, Yang& Liu, Longtao& Liang, Lin& Liu, Jiangang…[et al.]. Effects and Mechanism of Huannao Yicong Decoction Extract on the Ethology of Transgenic APPPS1 Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1155019
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155019
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر