Retracted: Topical Treatment with Xiaozheng Zhitong Paste (XZP)‎ Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKLRANKOPG Signaling

الملخص EN

Evidence-Based Complementary and Alternative Medicine has retracted the article titled “Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKL/RANK/OPG Signaling” [1].

As raised on PubPeer [2], the article was found to contain images with signs of duplication and manipulation in Figures 2 and 5.(i)The medium dose panel in Figure 2(b), showing 3D micro-CT images of the tibia, shows high similarity to parts of the Placebo and High-dose panels and may be a composite image:(1)The upper part of the Medium dose is similar to the upper part of the Placebo panel.(2)The lower part of the Medium-dose panel is similar to the lower part of the High-dose panel.(ii)Figures 5(a) and 5(b) include repeated images:(1)In Figure 5(a), the bottom right of the Control panel is the same as the top left of the Medium-dose panel.(2)In Figure 5(b), the top right of the Low-dose panel is the same as the bottom left of the High-dose panel.(iii)Comparing the submitted figures to the published figures:(1)In Figure 2(b), the 3D micro-CT images of the tibias are not the same between the submitted, accepted, and published versions of the article and show clear signs of editing.(2)In Figure 5(b), the High-dose panel in the submitted version is the same as the Medium-dose panel in the published version, but vertically stretched.(3)The High-dose panel in Figure 5(a) in the submitted version is the same as the Low-dose panel in Figure 5(b) in the published version.