Effect of Orally Administered Atractylodes macrocephala Koidz Water Extract on Macrophage and T Cell Inflammatory Response in Mice
المؤلفون المشاركون
Kim, Jong-In
Kim, Dae-Ok
Kang, Hee
Kwak, Tae-Kyung
Jang, Hyung-Seok
Lee, Mi-Gi
Jung, Young-Sung
Kim, Yoon-Bum
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The rhizome of Atractylodes macrocephala Koidz (AM) is a constituent of various Qi booster compound prescriptions.
We evaluated inflammatory responses in macrophages and T cells isolated from mice following oral administration of AM water extract (AME).
Peritoneal exudate cells were isolated from thioglycollate-injected mice and alterations in scavenger receptors were examined.
Peritoneal macrophages were stimulated with lipopolysaccharide (LPS).
Serum cytokine responses to intraperitoneal LPS injection were also evaluated.
Splenocytes were isolated and their composition and functional responses were measured.
The content of atractylenolide I and atractylenolide III, known anti-inflammatory ingredients, in AME was 0.0338 mg/g extract and 0.565 mg/g extract, respectively.
AME increased the number of SRA(+)CD11b(+) cells in response to thioglycollate.
Peritoneal macrophages isolated from the AME group showed no changes in inflammatory markers such as tumor necrosis factor- (TNF-) α, interleukin- (IL-) 6, inducible nitric oxide synthase, and cyclooxygenase-2 but exhibited a decrease in CD86 expression.
Interestingly, AME decreased the serum levels of TNF-α and IL-6 upon intraperitoneal injection of LPS.
Regarding the adaptive immune system, AME increased the CD4(+) T cell population and major histocompatibility complex class II molecule expression in the spleen, and cultured splenocytes from the AME group showed increased production of IL-4 concurrent with decreased interferon-γ production during T cell activation.
AME promoted the replenishment of peritoneal macrophages during the inflammatory response but its anti-inflammatory activity did not appear to be mediated by the modulation of macrophage activity.
AME also altered the immune status of CD4 T cells, promoting the Th2 response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kwak, Tae-Kyung& Jang, Hyung-Seok& Lee, Mi-Gi& Jung, Young-Sung& Kim, Dae-Ok& Kim, Yoon-Bum…[et al.]. 2018. Effect of Orally Administered Atractylodes macrocephala Koidz Water Extract on Macrophage and T Cell Inflammatory Response in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155060
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kwak, Tae-Kyung…[et al.]. Effect of Orally Administered Atractylodes macrocephala Koidz Water Extract on Macrophage and T Cell Inflammatory Response in Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1155060
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kwak, Tae-Kyung& Jang, Hyung-Seok& Lee, Mi-Gi& Jung, Young-Sung& Kim, Dae-Ok& Kim, Yoon-Bum…[et al.]. Effect of Orally Administered Atractylodes macrocephala Koidz Water Extract on Macrophage and T Cell Inflammatory Response in Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155060
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155060
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر