Expression of Oncostatin M in Early Gastric Cancer and Precancerous Lesions
المؤلفون المشاركون
Shi, Jihua
Xu, Xue
Du, Jun
Cui, Haimeng
Luo, Qingfeng
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To detect the expression of the Oncostatin M (OSM) gene and encoded protein in the mucosal epithelium of chronic gastritis, intestinal metaplasia (IM), low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), early gastric cancer (EGC), and advanced gastric cancer (AGC) samples and to explore the correlation and clinicopathological significance of OSM expression in the process of gastric carcinogenesis.
Methods.
The expression levels of OSM in chronic gastritis, IM, LGIN, HGIN, EGC, and AGC samples were detected by gene chip, real-time quantitative PCR, and immunohistochemical methods.
The expression levels of OSM in the gastric mucosa were analyzed, and its correlation with clinical pathology was studied.
Results.
The expression level of OSM in gastric HGIN and EGC tissues was significantly higher than that in LGIN tissues based on expression profiling (P<0.001).
The expression of the OSM gene in EGC was higher than that in HGIN (unpaired t test, P<0.05) and LGIN (unpaired t test, P<0.01) by qPCR.
The expression of OSM in LGIN was significantly lower than that in HGIN (P=0.008) and EGC (P=0.044) by immunohistochemical staining.
The expression of OSM in HGIN tissues was significantly higher than that in AGC (P=0.007).
Conclusion.
Alterations in the expression of the OSM gene may be involved in the malignant transformation of the gastric mucosal epithelium.
Because of the significant difference in the cancerization rate and clinical management between LGIN and HGIN, the difference in the staining intensity of OSM between LGIN and HGIN may be one of the early markers of gastric intraepithelial neoplasia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Jihua& Xu, Xue& Du, Jun& Cui, Haimeng& Luo, Qingfeng. 2019. Expression of Oncostatin M in Early Gastric Cancer and Precancerous Lesions. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155114
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Jihua…[et al.]. Expression of Oncostatin M in Early Gastric Cancer and Precancerous Lesions. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155114
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Jihua& Xu, Xue& Du, Jun& Cui, Haimeng& Luo, Qingfeng. Expression of Oncostatin M in Early Gastric Cancer and Precancerous Lesions. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155114
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155114
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر