Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients
المؤلفون المشاركون
Xia, Sheng-Long
Ying, Shi-Jie
Lin, Qian-Ru
Wang, Xiao-Qi
Hong, Wei-Jun
Lin, Zi-Jian
Luo, Jia-Kai
Jiang, Yi
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Abnormalities of forkhead box P3 (FOXP3) are implicated in various autoimmune diseases.
This study is aimed at investigating the association of ulcerative colitis (UC) with FOXP3 polymorphisms and its colonic expression in Chinese patients.
Polymorphisms of rs3761548, rs2232365, rs2294021, and rs3761547 were examined in 472 UC patients and 525 healthy controls using the SNaPshot method.
The colonic expression of FOXP3 mRNA and protein was assayed in inflammatory mucosa of 34 UC patients and normal mucosa of 36 patients with benign sigmoid polyps (normal controls) using real-time quantitative polymerase chain reaction and immunohistochemical analysis.
All data were handled separately for females and males.
As a result, the carrier frequencies with at least one variant allele of rs3761548, rs2232365, and rs229402 increased in female and male UC patients compared with healthy controls.
Significant differences in these carrier frequencies were also observed between patients with mild and moderate UC and patients with severe UC.
The expression of FOXP3 was higher in UC patients (both males and females), especially those with severe UC, than in normal controls.
The expression of FOXP3 was downregulated in UC patients having at least one variant allele compared with UC patients having no variant allele of rs3761548, rs2232365, and rs2294021.
Male gender (β=−0.341), rs2294021 variation (β=−0.503), and severe UC (β=0.361) were independently related to the mRNA expression of FOXP3 in UC patients.
Together, our findings indicated that FOXP3 (rs3761548, rs2232365, and rs2294021) variations increased the risk of UC and were associated with the lower colonic expression of FOXP3 in UC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xia, Sheng-Long& Ying, Shi-Jie& Lin, Qian-Ru& Wang, Xiao-Qi& Hong, Wei-Jun& Lin, Zi-Jian…[et al.]. 2019. Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155138
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xia, Sheng-Long…[et al.]. Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients. Gastroenterology Research and Practice No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1155138
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xia, Sheng-Long& Ying, Shi-Jie& Lin, Qian-Ru& Wang, Xiao-Qi& Hong, Wei-Jun& Lin, Zi-Jian…[et al.]. Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155138
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155138
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر