Four-Factor Prothrombin Complex Concentrate Reduces Time to Procedure in Vitamin K Antagonist-Treated Patients Experiencing Gastrointestinal Bleeding: A Post Hoc Analysis of Two Randomized Controlled Trials
المؤلفون المشاركون
Refaai, Majed A.
Kothari, Truptesh H.
Straub, Shana
Falcon, Jacob
Sarode, Ravi
Goldstein, Joshua N.
Brainsky, Andres
Omert, Laurel
Milling, Truman J.
Lee, Martin L.
المصدر
Emergency Medicine International
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
To investigate the impact of a 4-factor prothrombin complex concentrate (4F-PCC [Beriplex®/Kcentra®]) versus plasma on “time to procedure” in patients with acute/severe gastrointestinal bleeding requiring rapid vitamin K antagonist (VKA) reversal prior to invasive procedure.
Methods.
A post hoc analysis of two phase III trials of 4F-PCC versus plasma in patients with acute/severe gastrointestinal bleeding.
The treatment arms were compared for study treatment volume, infusion times, and time from start of study treatment to procedure.
Results.
Analysis included 42 patients (plasma, n=20; 4F-PCC, n=22).
Median (interquartile range) infusion time was significantly shorter for the 4F-PCC group than for the plasma group (16 [13, 26] min versus 210 [149, 393] min; P<0.0001).
Median infusion volumes were significantly smaller (103 [80, 130] mL versus 870 [748, 1001] mL; P<0.0001) and median time from study treatment initiation to first procedure was significantly shorter in the 4F-PCC group than in the plasma group (17.5 [12.8, 22.8] versus 23.9 [18.5, 62.0] h; P=0.037).
Conclusions.
In this analysis of patients with acute/severe gastrointestinal bleeding requiring urgent VKA reversal prior to an invasive procedure, 4F-PCC (compared with plasma) was associated with smaller infusion volumes, shorter infusion times, and reduced time to procedure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Refaai, Majed A.& Kothari, Truptesh H.& Straub, Shana& Falcon, Jacob& Sarode, Ravi& Goldstein, Joshua N.…[et al.]. 2017. Four-Factor Prothrombin Complex Concentrate Reduces Time to Procedure in Vitamin K Antagonist-Treated Patients Experiencing Gastrointestinal Bleeding: A Post Hoc Analysis of Two Randomized Controlled Trials. Emergency Medicine International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1155205
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Refaai, Majed A.…[et al.]. Four-Factor Prothrombin Complex Concentrate Reduces Time to Procedure in Vitamin K Antagonist-Treated Patients Experiencing Gastrointestinal Bleeding: A Post Hoc Analysis of Two Randomized Controlled Trials. Emergency Medicine International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1155205
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Refaai, Majed A.& Kothari, Truptesh H.& Straub, Shana& Falcon, Jacob& Sarode, Ravi& Goldstein, Joshua N.…[et al.]. Four-Factor Prothrombin Complex Concentrate Reduces Time to Procedure in Vitamin K Antagonist-Treated Patients Experiencing Gastrointestinal Bleeding: A Post Hoc Analysis of Two Randomized Controlled Trials. Emergency Medicine International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1155205
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155205
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر