R-Limonene Enhances Differentiation and 2-Deoxy-D-Glucose Uptake in 3T3-L1 Preadipocytes by Activating the Akt Signaling Pathway
المؤلفون المشاركون
Ilavenil, Soundharrajan
Choi, Ki Choon
Srigopalram, Srisesharam
Kim, Da Hye
Kuppusamy, Palaniselvem
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Adipocyte is an important place for lipid storage.
Defects in lipid storage in adipocytes can lead to lipodystrophy and lipid accumulation in muscle, liver, and other organs.
It is the condition of mixed dyslipidemia which may favor the development of insulin resistance via lipotoxic mechanisms.
Our objective of the study was to investigate the potential role of R-limonene (LM) on differentiation, lipid storage, and 2-deoxy-D-glucose (2DG) uptake in 3T3-L1 preadipocytes.
Genes and proteins associated with differentiation, lipid accumulation, 2DG uptake and its signaling pathways in the adipocytes were analyzed using qPCR and western blot methods.
LM treatment increased differentiation, lipid accumulation, and the expression of adipogenic and lipogenic markers such as C/EBP-α, C/EBP-β, PPARγ, SREBP-1, RXR, FAS, and adiponectin.
However, the LM concentration at 10μM decreased (p < 0.05) adipogenesis and lipogenesis via regulating key transcriptional factors.
LM treatment increased activation of Akt by increasing its phosphorylation, but p44/42 activation was not altered.
MK-2206, an Akt specific inhibitor, reduced the activation of Akt phosphorylation whereas LM treatment aborted the MK-2206 mediated inhibition of Akt activation.
LM enhanced glucose uptake in differentiated adipocytes.
Overall data suggested that LM treatment favored lipid storage and glucose uptake in adipocytes via activation of key transcriptional factors through activation of Akt phosphorylation in 3T3-L1 adipocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ilavenil, Soundharrajan& Kim, Da Hye& Srigopalram, Srisesharam& Kuppusamy, Palaniselvem& Choi, Ki Choon. 2018. R-Limonene Enhances Differentiation and 2-Deoxy-D-Glucose Uptake in 3T3-L1 Preadipocytes by Activating the Akt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155228
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ilavenil, Soundharrajan…[et al.]. R-Limonene Enhances Differentiation and 2-Deoxy-D-Glucose Uptake in 3T3-L1 Preadipocytes by Activating the Akt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155228
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ilavenil, Soundharrajan& Kim, Da Hye& Srigopalram, Srisesharam& Kuppusamy, Palaniselvem& Choi, Ki Choon. R-Limonene Enhances Differentiation and 2-Deoxy-D-Glucose Uptake in 3T3-L1 Preadipocytes by Activating the Akt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155228
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155228
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر