Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research
المؤلفون المشاركون
Mirnezami, Reza
Koumpa, Foteini Stefania
Xylas, Diamantis
Konopka, Maciej
Galea, Dieter
Veselkov, Kirill
Antoniou, Anthony
Mehta, Akash
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-30، 30ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-01
دولة النشر
مصر
عدد الصفحات
30
التخصصات الرئيسية
الملخص EN
Colorectal peritoneal metastases (CPM) are associated with abbreviated survival and significantly impaired quality of life.
In patients with CPM, radical multimodality treatment consisting of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has demonstrated oncological superiority over systemic chemotherapy alone.
In highly selected patients undergoing CRS + HIPEC, overall survival of over 60% has been reported in some series.
These are patients in whom the disease burden is limited and where the diagnosis is made at an early stage in the disease course.
Early diagnosis and a deeper understanding of the biological mechanisms that regulate CPM are critical to refining patient selection for radical treatment, personalising therapeutic approaches, enhancing prognostication, and ultimately improving long-term survivorship.
In the present study, we outline three broad themes which represent critical future research targets in CPM: (1) enhanced radiological strategies for early detection and staging; (2) identification and validation of translational biomarkers for diagnostic, prognostic, and therapeutic deployment; and (3) development of optimized approaches for surgical cytoreduction as well as more precise strategies for intraperitoneal drug selection and delivery.
Herein, we provide a contemporary narrative review of the state of the art in these three areas.
A systematic review in accordance with PRISMA guidelines was undertaken on all English language studies published between 2007 and 2017.
In vitro and animal model studies were deemed eligible for inclusion in the sections pertaining to biomarkers and therapeutic optimisation, as these areas of research currently remain in the early stages of development.
Acquired data were then divided into hierarchical thematic categories (imaging modalities, translational biomarkers (diagnostic/prognostic/therapeutic), and delivery techniques) and subcategories.
An interactive sunburst figure is provided for intuitive interrogation of the CPM research landscape.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Koumpa, Foteini Stefania& Xylas, Diamantis& Konopka, Maciej& Galea, Dieter& Veselkov, Kirill& Antoniou, Anthony…[et al.]. 2019. Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-30.
https://search.emarefa.net/detail/BIM-1155236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Koumpa, Foteini Stefania…[et al.]. Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research. Gastroenterology Research and Practice No. 2019 (2019), pp.1-30.
https://search.emarefa.net/detail/BIM-1155236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Koumpa, Foteini Stefania& Xylas, Diamantis& Konopka, Maciej& Galea, Dieter& Veselkov, Kirill& Antoniou, Anthony…[et al.]. Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-30.
https://search.emarefa.net/detail/BIM-1155236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر