RACK1 Acts as a Potential Tumor Promoter in Colorectal Cancer
المؤلفون المشاركون
Zhu, Yin
Li, Xue-Yang
Hu, Yi
Li, Nian-Shuang
Wan, Jian-Hua
Lu, Nong-Hua
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The receptor of activated protein kinase C 1 (RACK1) promotes the progression and invasion of several cancers.
However, the role of RACK1 in the pathogenesis of colorectal cancer (CRC) has not been clearly defined.
Herein, we aimed to investigate the biological role of RACK1 in CRC.
Materials and Methods.
The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) dataset were searched, and the expression of RACK1 in CRC tissues and adjacent normal tissues was evaluated.
Immunohistochemical staining was performed to detect the expression of RACK1 in human CRC, adenoma, and normal tissues.
Western blotting was used to detect the expression of RACK1 in human CRC cell lines.
Functional assays, such as BrdU, colony formation, and wound healing and transwell invasion assays, were used to explore the biological role of RACK1 in CRC.
Results.
RACK1 was upregulated in CRC tissues compared with its expression in adjacent normal tissues in TCGA and the GEO dataset (P<0.05).
Moreover, RACK1 was significantly overexpressed in CRC and adenoma tissues compared with its expression in normal tissues (P<0.05).
Loss-of-function experiments showed that RACK1 promoted cell proliferation, migration, and invasion in vitro.
Conclusions.
Our data indicated that RACK1, as an oncogene, markedly promoted the progression of CRC, which suggested that RACK1 is a potential therapeutic target for CRC management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xue-Yang& Hu, Yi& Li, Nian-Shuang& Wan, Jian-Hua& Zhu, Yin& Lu, Nong-Hua. 2019. RACK1 Acts as a Potential Tumor Promoter in Colorectal Cancer. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155260
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xue-Yang…[et al.]. RACK1 Acts as a Potential Tumor Promoter in Colorectal Cancer. Gastroenterology Research and Practice No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1155260
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xue-Yang& Hu, Yi& Li, Nian-Shuang& Wan, Jian-Hua& Zhu, Yin& Lu, Nong-Hua. RACK1 Acts as a Potential Tumor Promoter in Colorectal Cancer. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155260
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155260
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر