Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
المؤلفون المشاركون
D'Albuquerque, Luiz Augusto Carneiro
Galvao, Flavio H. F.
Figueira, Estela Regina Ramos
Rocha-Filho, Joel Avancini
Lanchotte, Cinthia
Coelho, Ana Maria Mendonça
Nakatani, Mauro
Tatebe, Eduardo Ryoiti
Lima, Jonathan Augusto Venceslau
Mendes, Camilla Oliveira
de Araujo, Bruno Camargo Rocha Paim
Abdo, Emilio Elias
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury.
This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model.
Materials and Methods.
Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min during reperfusion).
Results.
All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia.
After 4 h of reperfusion, only the SPPoC group had MAP recovery.
In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels.
Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion.
Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia.
Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Figueira, Estela Regina Ramos& Rocha-Filho, Joel Avancini& Lanchotte, Cinthia& Coelho, Ana Maria Mendonça& Nakatani, Mauro& Tatebe, Eduardo Ryoiti…[et al.]. 2019. Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155279
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Figueira, Estela Regina Ramos…[et al.]. Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155279
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Figueira, Estela Regina Ramos& Rocha-Filho, Joel Avancini& Lanchotte, Cinthia& Coelho, Ana Maria Mendonça& Nakatani, Mauro& Tatebe, Eduardo Ryoiti…[et al.]. Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155279
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155279
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر