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Safety and Efficacy of Nonanesthesiologist-Administrated Propofol during Endoscopic Submucosal Dissection of Gastric Epithelial Tumors
المؤلفون المشاركون
Irisawa, Atsushi
Kanamori, Akira
Abe, Keiichiro
Tominaga, Keiichi
Suzuki, Tsunehiro
Kino, Hitoshi
Nakano, Masakazu
Sugaya, Takeshi
Tsuchida, Kouhei
Majima, Yuichi
Murohisa, Toshimitsu
Iijima, Makoto
Goda, Kenichi
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
There is no consensus regarding administration of propofol for performing endoscopic submucosal dissection (ESD) in patients with comorbidities.
The aim of this study was to evaluate the safety and efficacy of propofol-induced sedation administered by nonanesthesiologists during ESD of gastric cancer in patients with comorbidities classified according to the American Society of Anesthesiologists (ASA) physical status.
Methods.
Five hundred and twenty-two patients who underwent ESD for gastric epithelial tumors under sedation by nonanesthesiologist-administrated propofol between April 2011 and October 2017 at Dokkyo Medical University Hospital were enrolled in this study.
The patients were divided into 3 groups according to the ASA physical status classification.
Hypotension, desaturation, and bradycardia were evaluated as the adverse events associated with propofol.
The safety of sedation by nonanesthesiologist-administrated propofol was measured as the primary outcome.
Results.
The patients were classified according to the ASA physical status classification: 182 with no comorbidity (ASA 1), 273 with mild comorbidity (ASA 2), and 67 with severe comorbidity (ASA 3).
The median age of the patients with ASA physical status of 2/3 was higher than the median age of those with ASA physical status of 1.
There was no significant difference in tumor characteristics, total amount of propofol used, or ESD procedure time, among the 3 groups.
Adverse events related to propofol in the 522 patients were as follows: hypotension (systolic blood pressure<90 mmHg) in 113 patients (21.6%), respiratory depression (SpO2<90%) in 265 patients (50.8%), and bradycardia (pulse rate<50 bpm) in 39 patients (7.47%).
There was no significant difference in the incidences of adverse events among the 3 groups during induction, maintenance, or recovery.
No severe adverse event was reported.
ASA 3 patients had a significantly longer mean length of hospital stay (8 days for ASA 1, 9 days for ASA 2, and 9 days for ASA 3, P=0.003).
However, the difference did not appear to be clinically significant.
Conclusions.
Sedation by nonanesthesiologist-administrated propofol during ESD is safe and effective, even for at-risk patients according to the ASA physical status classification.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abe, Keiichiro& Tominaga, Keiichi& Kanamori, Akira& Suzuki, Tsunehiro& Kino, Hitoshi& Nakano, Masakazu…[et al.]. 2019. Safety and Efficacy of Nonanesthesiologist-Administrated Propofol during Endoscopic Submucosal Dissection of Gastric Epithelial Tumors. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abe, Keiichiro…[et al.]. Safety and Efficacy of Nonanesthesiologist-Administrated Propofol during Endoscopic Submucosal Dissection of Gastric Epithelial Tumors. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abe, Keiichiro& Tominaga, Keiichi& Kanamori, Akira& Suzuki, Tsunehiro& Kino, Hitoshi& Nakano, Masakazu…[et al.]. Safety and Efficacy of Nonanesthesiologist-Administrated Propofol during Endoscopic Submucosal Dissection of Gastric Epithelial Tumors. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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