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Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng
المؤلفون المشاركون
Yoo, Jae-Myung
Kim, Jungeun
Kim, Jin Soo
Kim, Sun-Gun
Park, Jong Eel
Seok, Young Mi
Son, Jun-Ho
Kim, Hyo Jung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Mountain ginseng has been used generally as a pharmacopuncture for cancer therapy in clinical practice in Northeast Asia.
Nonetheless, there have been few scientific reports for the anticancer action of mountain ginseng.
In this study, we investigated whether mountain ginseng extract (MGE) could inhibit the growth of breast cancer in in vitro and in vivo models.
MGE showed stronger cytotoxicity than farm-cultivated ginseng extract (FGE) through promoting ROS generation.
Also MGE dose-dependently brought about mitochondrial dysfunction in MCF-7 cells.
In addition, MGE induced apoptosis through enhancing the activities of caspase-3/7 by regulation of expression of Bcl-2, Bax, cytochrome c, and cleaved caspase-3 in the MCF-7 cells.
Consistent with the in vitro results, MGE significantly reduced tumor weights compared with FGE in mice transplanted with MCF-7 cells, and it regulated the expression of apoptosis-related proteins, such as Bcl-2, Bax, cytochrome c, cleaved caspase-3, and cleaved PARP, in the tumor tissues.
Additionally, MGE included higher total ginsenoside contents than FGE.
In conclusion, MGE, which is richer in ginsenosides, exerts a stronger anticancer action than FGE in breast cancer.
The anticancer action of MGE may be closely correlated with caspase-mediated apoptosis through upregulating ROS generation.
Therefore, these findings may be helpful for a clinical understanding of the anticancer mechanism of MGE for breast cancer patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Jungeun& Yoo, Jae-Myung& Kim, Jin Soo& Kim, Sun-Gun& Park, Jong Eel& Seok, Young Mi…[et al.]. 2020. Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155298
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Jungeun…[et al.]. Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155298
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Jungeun& Yoo, Jae-Myung& Kim, Jin Soo& Kim, Sun-Gun& Park, Jong Eel& Seok, Young Mi…[et al.]. Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155298
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155298
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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