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Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers
المؤلفون المشاركون
Zhu, Shengtao
Zhang, Shutian
Zhang, Lingye
Liu, Juan
Meng, Fandong
Guan, Yingying
Wang, Yongjun
Liu, Yaqiong
Xie, Qing
Yu, Junxian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Bismuth-containing quadruple therapy achieves higher eradication rate of Helicobacter pylori.
High level of bismuth in blood may result in damage of many organs.
Wei Bi Mei is a new bismuth-containing drug combining chemicals and Chinese medicine portions.
The present research is to study the pharmacokinetics of bismuth to evaluate the safety and rational use of Wei Bi Mei granules.
Material and Methods.
Seven healthy Chinese adult subjects were enrolled in this research, which included a single-dose study and a multiple-dose study.
Wei Bi Mei granules were administered orally to the subjects at corresponding time.
Blood and urine were collected.
All samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS).
Results.
For single-dose Wei Bi Mei granules administration, the mean time to peak concentration (tmax) of bismuth was 2.29 ± 0.76 h, and the mean peak concentration (Cmax) of bismuth was 0.85 ± 0.55 ng/mL.
For multiple-dose Wei Bi Mei granules administration, the Cmax was 2.25 ± 1.18 ng/mL at day two, and the volume of distribution (Vd) was (22.97 ± 9.82) × 103 L.
The urinary excretion of bismuth was the fastest during the first two days, with a mean excretion rate of 3.84 ± 1.23 ng/h.
The bismuth concentration in urine was significantly reduced at day 16.
Conclusion.
Bismuth has a washout period of approximately two months.
The concentration of bismuth in blood was far less than the “safe level.” Thus, Wei Bi Mei is a highly safe therapeutic medicine, with a good clinical application value.
Wei Bi Mei should be recommended more widely for use in bismuth-containing quadruple therapy for the treatment of Helicobacter pylori infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lingye& Liu, Juan& Meng, Fandong& Guan, Yingying& Wang, Yongjun& Zhu, Shengtao…[et al.]. 2020. Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1155341
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lingye…[et al.]. Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1155341
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lingye& Liu, Juan& Meng, Fandong& Guan, Yingying& Wang, Yongjun& Zhu, Shengtao…[et al.]. Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1155341
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155341
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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