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The Protective Effect of Teprenone on Aspirin-Related Gastric Mucosal Injuries
المؤلفون المشاركون
Zhao, Jing
Fan, Yihong
Ye, Wu
Feng, Wen
Hu, Yue
Cai, Lijun
Lu, Bin
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Aspirin usage is associated with increased risk of gastrointestinal bleeding.
The present study explored the potential of teprenone, an antiulcerative, in preventing aspirin-related gastric mucosal injuries.
Methods.
280 patients with coronary diseases, naïve to aspirin medication, were admitted between 2011 and 2013 at the First Affiliated Hospital of Zhejiang Chinese Medical University and randomized into two groups (n=140).
The aspirin group received aspirin enteric-coated tablets 100 mg/day, while the aspirin+teprenone group received teprenone 50 mg 3 times/day along with aspirin.
The patients were recorded for gastrointestinal symptoms and gastric mucosal injuries during a follow-up period of 12 months with 3-month intervals.
Results.
During the 3-month follow-up, no significant difference was observed in the incidence rate of gastrointestinal symptoms between the two groups (P=0.498).
However, the incidence rate of gastrointestinal symptoms was significantly lower in the aspirin+teprenone group than in the aspirin group during the follow-ups at 6 months (P=0.036) and 12 months (P=0.036).
The incidence rate of gastric mucosal injuries in the aspirin group was significantly increased at 12 months compared to that at 3 months (P=0.016).
The incidence rates at 12 months and cumulative for the entire follow-up period in the aspirin+teprenone group were both significantly lower than those of the aspirin group (P=0.049 and P=0.001, respectively).
Conclusion.
Long-term use of low-dose aspirin causes varying degrees of gastric mucosal damages and gastrointestinal symptoms; the severity will increase within a certain range with the extension of medication duration.
Teprenone mitigates the gastrointestinal symptoms caused by low-dose aspirin, lowering both the incidence and severity of gastric mucosal injuries and exerting a positive protective effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Jing& Fan, Yihong& Ye, Wu& Feng, Wen& Hu, Yue& Cai, Lijun…[et al.]. 2019. The Protective Effect of Teprenone on Aspirin-Related Gastric Mucosal Injuries. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Jing…[et al.]. The Protective Effect of Teprenone on Aspirin-Related Gastric Mucosal Injuries. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Jing& Fan, Yihong& Ye, Wu& Feng, Wen& Hu, Yue& Cai, Lijun…[et al.]. The Protective Effect of Teprenone on Aspirin-Related Gastric Mucosal Injuries. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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