Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3KAktNF-κBMMP-9 Signaling Pathway
المؤلفون المشاركون
Cao, Chenjie
Su, Ya
Gao, Yanqi
Luo, Chengrong
Yin, Lu
Zhao, Yingjie
Chen, Huasheng
Xu, Aihua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
In recent years, interest in natural plant extracts for cancer treatment is growing in the drug development field.
Ginkgo biloba exocarp extract (GBEE) is known for possessing inhibitory effects on various mouse and human cancer cells.
And no adverse reactions were observed during its clinical application to cancer patients.
The aim of this study is to investigate the inhibitory effect of GBEE on the metastasis of B16-F10 melanoma and its related mechanisms.
The B16-F10 melanoma lung metastasis model was established in C57BL/6J mice.
It was found that GBEE inhibited the growth and pulmonary metastasis of B16-F10 melanoma transplanted tumor and downregulated the level of MMP-9 protein.
Meanwhile, the B16-F10 cells were used to study in vitro.
The results showed that GBEE inhibited the proliferation and migration of B16-F10 cells.
Simultaneously, it suppressed the heterogeneous adhesion of B16-F10 cells to human umbilical vein endothelial cells (HUVEC) in a concentration-dependent manner.
In addition, the levels of p-PI3K, p-Akt, NF-κB, and MMP-9 were decreased, while the PI3K and Akt were not significantly changed.
These results indicate that GBEE can inhibit the metastasis of B16-F10 melanoma via multiple links and the molecular mechanism involved the regulation of PI3K/Akt/NF-κB/MMP-9 signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Chenjie& Su, Ya& Gao, Yanqi& Luo, Chengrong& Yin, Lu& Zhao, Yingjie…[et al.]. 2018. Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3KAktNF-κBMMP-9 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Chenjie…[et al.]. Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3KAktNF-κBMMP-9 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Chenjie& Su, Ya& Gao, Yanqi& Luo, Chengrong& Yin, Lu& Zhao, Yingjie…[et al.]. Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3KAktNF-κBMMP-9 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر