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Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation
المؤلفون المشاركون
Joo, Myungsoo
Choi, Jun-Yong
Kim, Kyun Ha
Won, Ran
Park, Soo Ryun
Kwun, Min Jung
Lee, Ji Yeon
Han, Chang Woo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Bojungikki-tang (BT), an Asian herbal remedy, has been prescribed to increase the vitality of debilitated patients.
Since a compromised, weakened vitality often leads to illness, BT has been widely used to treat various diseases.
However, little is known about the mechanism by which BT exerts its effect.
Given that BT ameliorates inflammatory pulmonary diseases including acute lung injury (ALI), we investigated whether BT regulates the function of key inflammatory factors such as NF-κB and Nrf2, contributing to suppressing inflammation.
Results show that BT interrupted the nuclear localization of NF-κB and suppressed the expression of the NF-κB-dependent genes in RAW 264.7 cells.
In similar experiments, BT induced the nuclear localization of Nrf2 and the expression of the Nrf2-dependent genes.
In a lipopolysaccharide-induced ALI mouse model, a single intratracheal administration of BT to mouse lungs ameliorated alveolar structure and suppressed the expression of proinflammatory cytokine genes and neutrophil infiltration to mouse lungs.
Therefore, our findings suggest that suppression of NF-κB and activation of Nrf2, by which BT suppresses inflammation, are ways for BT to exert its effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Soo Ryun& Kim, Kyun Ha& Kwun, Min Jung& Lee, Ji Yeon& Won, Ran& Han, Chang Woo…[et al.]. 2018. Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155392
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Soo Ryun…[et al.]. Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155392
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Soo Ryun& Kim, Kyun Ha& Kwun, Min Jung& Lee, Ji Yeon& Won, Ran& Han, Chang Woo…[et al.]. Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155392
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155392
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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