In Vitro and In Vivo Anti-AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer’s Disease
المؤلفون المشاركون
Song, Xinmeng
Wang, Tiejie
Guo, Linxiu
Jin, Yibao
Wang, Jue
Yin, Guo
Jiang, Kun
Wang, Lijun
Huang, Hongrong
Zeng, Long
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Acetylcholinesterase (AChE) inhibition and antioxidants are two common strategies for the treatment in the early stage of Alzheimer’s Disease (AD).
In this study, extracts from nine traditional Chinese medical (TCM) herbs were tested for anti-AChE activity by Ellman’s microplate assay and cytotoxicity by CCK-8.
Based on its excellent AChE inhibition effect and its lowest cytotoxicity, Schisandra chinensis (SC) extract was selected to do the mechanism research.
SC extract protected pheochromocytoma (PC12) cells against H2O2-induced toxicity by improving the cell survival rate in a dose-dependent manner.
And it also showed significant free radical (DPPH) scavenging activities, ferric reducing antioxidant power (FRAP), and 2,2′-Azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging.
To confirm these results, the scopolamine-induced mice models were utilized in this study.
Compared with the positive drug (piracetam), SC could also exhibit similar effects to alleviate the mice’s cognitive deficits.
Moreover, in the mice brain samples, the AChE activity and malondialdehyde (MDA) levels of SC-treatment group both showed a reverse as compared to model group.
Taken together, these results all suggested that SC extract may be a potential therapeutic candidate for AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Xinmeng& Wang, Tiejie& Guo, Linxiu& Jin, Yibao& Wang, Jue& Yin, Guo…[et al.]. 2020. In Vitro and In Vivo Anti-AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155424
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Xinmeng…[et al.]. In Vitro and In Vivo Anti-AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155424
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Xinmeng& Wang, Tiejie& Guo, Linxiu& Jin, Yibao& Wang, Jue& Yin, Guo…[et al.]. In Vitro and In Vivo Anti-AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155424
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155424
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر