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Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents
المؤلفون المشاركون
Asrade Atnafe, Seyfe
Abdulwuhab, Mohammedbrhan
Mekonnen, Alefe Norahun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Peptic ulcer disease causes significant mortality and morbidity.
Plant kingdom provides a useful source for the development of new antiulcer agents.
Croton macrostachyus is traditionally used to treat peptic ulcer in Ethiopia.
This study aimed to evaluate the antiulcer activity of C.
macrostachyus root extracts in rodents using different models.
Methods.
The crude extract was obtained by cold maceration in 80% methanol and fractionated with chloroform, ethyl acetate, and distilled water.
The antiulcer activity was evaluated using pylorus ligation-induced ulcer model in Sprague Dawley rats and acidified ethanol-induced ulcer model in Swiss albino mice.
The test groups received three doses (100, 200, and 400 mg/kg) of the crude extract and fractions for 7 days before induction of ulcer.
Positive controls received omeprazole 30 mg/kg for the pylorus ligation-induced ulcer model and sucralfate 100 mg/kg for the acidified ethanol-induced ulcer model.
Negative controls received vehicle (2% tween 80).
Results.
The crude hydromethanolic extract of C.
macrostachyus showed significant (p<0.05) antiulcer activity on both pyloric ligation and HCl/ethanol-induced ulcer in rats and mice.
It has antisecretary effect (p<0.001) as well.
All three administered doses of chloroform fraction (p<0.05) and only higher doses of ethyl acetate fraction (p<0.05) possessed significant antiulcer activity.
In contrast, the aqueous fraction did not have significant antiulcer effect at all tested doses.
Conclusion.
The present study demonstrated that the crude extract, chloroform, and ethyl acetate fractions possessed significant dose-dependent antiulcer activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mekonnen, Alefe Norahun& Asrade Atnafe, Seyfe& Abdulwuhab, Mohammedbrhan. 2020. Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mekonnen, Alefe Norahun…[et al.]. Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mekonnen, Alefe Norahun& Asrade Atnafe, Seyfe& Abdulwuhab, Mohammedbrhan. Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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