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Effects and Mechanisms of Dendrobium officinalis Six Nostrum for Treatment of Hyperuricemia with Hyperlipidemia
المؤلفون المشاركون
Li, Bo
Chen, Su-Hong
Lv, Gui-Yuan
Lei, Shan-Shan
Guo, Lin-Feng
Chen, Xue
Zhang, Ning-Yu
Ge, Hong-Zhang
Yang, Ke
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objectives.
Hyperuricemia (HUA) is a disease caused by increased production of uric acid (UA) or reduced excretion of UA in the body.
Results of an epidemiological survey show that 60% of patients with HUA have hyperlipidemia (HPA).
Dendrobium officinalis (DOF) six nostrum (DOS) is based on the theory of traditional Chinese medicine for the transformation of the traditional Chinese nostrum Si Miao Wan.
In this article, we aim to discuss the efficacy and mechanism of DOS in reducing UA and regulating lipid metabolism.
The rat model of HUA with HPA was induced by potassium oxonate (PO) combined with high-fat sorghum feed.
We monitored the serum UA and blood lipids.
Liver xanthine oxidase (XOD), adenosine deaminase (ADA), lipoprotein lipase (LPL), and fatty acid-binding protein (FABP1) activities were measured by enzyme-linked immunosorbent assay (ELISA) after the last administration of DOS.
We performed a histopathological examination of rat kidney and intestine.
Immunohistochemistry (IHC) was used to detect the expression of renal inflammatory proteins NLRP3 / Caspase-1 and intestinal inflammatory proteins TLR4 / NLRP3.
We used western blot for measurement of liver hypoxanthine-guanine phosphoribosyl transferase (HPRT1) protein expression and renal PDZ domain protein kidney 1 (PDZK1) protein expression.
DOS administration significantly reduced serum UA, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) level, and improved liver steatosis in the model rat.
At the same time, DOS treatment effectively inhibited liver XOD and ADA, increased the level of liver HPRT1, and reduced the production of UA.
Additional studies had shown that DOS can restore normal UA excretion function in the intestine and kidney and regulated liver lipids metabolism.
IHC and histopathological sections showed that DOS reduced the level of kidney, intestinal inflammatory body (NLRP3, Caspase-1, and TLR4), improved inflammation of the kidney and intestinal tract in rats.
DOS is a promising drug that can effectively reduce serum UA and lipid level in the model rat.
The mechanism of action may be related to inhibition of UA production, promotion of UA excretion, regulation of lipids metabolism, and anti-inflammatory response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Lin-Feng& Chen, Xue& Lei, Shan-Shan& Li, Bo& Zhang, Ning-Yu& Ge, Hong-Zhang…[et al.]. 2020. Effects and Mechanisms of Dendrobium officinalis Six Nostrum for Treatment of Hyperuricemia with Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155471
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Lin-Feng…[et al.]. Effects and Mechanisms of Dendrobium officinalis Six Nostrum for Treatment of Hyperuricemia with Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1155471
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Lin-Feng& Chen, Xue& Lei, Shan-Shan& Li, Bo& Zhang, Ning-Yu& Ge, Hong-Zhang…[et al.]. Effects and Mechanisms of Dendrobium officinalis Six Nostrum for Treatment of Hyperuricemia with Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155471
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155471
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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