Qingxin Kaiqiao Recipe Improves Cognitive Performance, Inhibits Apoptosis, and Reduces Pathological Deposits in APPPS1 Double Transgenic Mice via the PI3KAkt Pathway
المؤلفون المشاركون
Lin, Shi-Yi
Wang, Tian-Qi
Xu, Lu-Ting
Lai, Xiao-Xiao
Shen, Yan
Lin, Jian-Wei
Gao, Shi-Yu
Hu, Hai-Yan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The traditional Chinese medicine of Qingxin Kaiqiao Recipe (QKR) is effective in the treatment of Alzheimer’s disease (AD).
This study aims to investigate whether QKR improves the cognitive ability and takes neuroprotective effect on APP/PS1 double transgenic mice via the PI3K/Akt pathway.
APP/PS1 double transgenic mice were randomly divided into a model, donepezil-treated, or QKR-treated group (L-QKR: 4.75 mg/kg/d, M-QKR: 9.5 mg/kg/d, and H-QKR: 19 mg/kg/d, respectively).
Wild-type C57/BL6J mice were used as the control group.
Morris water maze (MWM) was used to test the ability of spatial navigation and memorization; terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelling (TUNEL) assay was applied to test the apoptosis; amyloid protein granule deposition was detected via Methenamine silver staining; Western blot (WB) analysis, immunohistochemistry, and RT-PCR were applied to measure the expression of Aβ and corresponding indicators of the PI3K/Akt pathway.
Compared with the model group, QKR significantly relieved the cognitive impairment, reduced the deposition of senile plaques, decreased the expression of GSK-3α and Aβ, and increased the expression of p-PI3K, p-Akt, and IDE.
In addition, the number of TUNEL-positive cells decreased after treatment using QKR.
The current study proved that QKR, especially at the high dose tested, exerted a protective effect on improving learning and memory, inhibiting apoptosis, and reducing the process of pathological degeneration in the hippocampus of AD mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Shi-Yi& Wang, Tian-Qi& Xu, Lu-Ting& Lai, Xiao-Xiao& Shen, Yan& Lin, Jian-Wei…[et al.]. 2020. Qingxin Kaiqiao Recipe Improves Cognitive Performance, Inhibits Apoptosis, and Reduces Pathological Deposits in APPPS1 Double Transgenic Mice via the PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1155519
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Shi-Yi…[et al.]. Qingxin Kaiqiao Recipe Improves Cognitive Performance, Inhibits Apoptosis, and Reduces Pathological Deposits in APPPS1 Double Transgenic Mice via the PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1155519
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Shi-Yi& Wang, Tian-Qi& Xu, Lu-Ting& Lai, Xiao-Xiao& Shen, Yan& Lin, Jian-Wei…[et al.]. Qingxin Kaiqiao Recipe Improves Cognitive Performance, Inhibits Apoptosis, and Reduces Pathological Deposits in APPPS1 Double Transgenic Mice via the PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1155519
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155519
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر