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Diagnostic and Clinical Significance of Serum Levels of D-Lactate and Diamine Oxidase in Patients with Crohn’s Disease
المؤلفون المشاركون
Cai, Jierui
Chen, Hong
Weng, Meiling
Jiang, Shuyu
Gao, Jie
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Crohn’s disease (CD) is a chronic intestinal inflammatory disease.
An ideal laboratory marker that can predict the prognosis in terms of relapse of the disease is clinically desirable.
Methods.
A total of 59 CD patients were enrolled in this study.
Enzyme-Linked Immunosorbent Assay (ELISA) was used to quantitatively detect the content of D-lactate (D-LA) and the diamine oxidase (DAO) levels in sera obtained from patients and 28 healthy controls.
The correlation between these two biomarkers and disease activity scores was assessed.
In addition, the ROC curve was used to evaluate the diagnostic accuracy of these two biomarkers.
Results.
The levels of D-LA in the serum of CD patients in the active stage and remission stage were 16.08±4.8 mg/L and 11.16±3.17 mg/L, respectively, and the difference was statistically significant (t=4.67, P<0.001).
DAO levels were significantly higher in patients with the active stage compared to controls.
The levels of D-LA and DAO in CD patients were positively correlated with the disease activity (r=0.68 and 0.53, respectively, P<0.05).
The area under the ROC curve (AUC) when CD activity was diagnosed with D-LA and DAO alone was 0.815 and 0.748, respectively.
The diagnostic efficacy of the two biomarkers was not significantly different from that of the erythrocyte sedimentation (ESR) and hypersensitive C-reactive protein (CRP) (P>0.05).
However, the area under the curve was 0.861 (0.746, 0.937) when the diagnosis was performed using a combination of D-LA, DAO, CRP, and ESR, which was significantly higher than when CRP or ESR were tested alone (P<0.05).
Conclusions.
D-LA and DAO have a good prognostic value for CD activity.
Rational combined use of biomarkers can significantly improve the diagnostic efficiency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Jierui& Chen, Hong& Weng, Meiling& Jiang, Shuyu& Gao, Jie. 2019. Diagnostic and Clinical Significance of Serum Levels of D-Lactate and Diamine Oxidase in Patients with Crohn’s Disease. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155523
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Jierui…[et al.]. Diagnostic and Clinical Significance of Serum Levels of D-Lactate and Diamine Oxidase in Patients with Crohn’s Disease. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155523
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Jierui& Chen, Hong& Weng, Meiling& Jiang, Shuyu& Gao, Jie. Diagnostic and Clinical Significance of Serum Levels of D-Lactate and Diamine Oxidase in Patients with Crohn’s Disease. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155523
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155523
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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