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The Pre- and Postoperative FIB-4 Indexes Are Good Predictors to the Outcomes of HBV-Related HCC Patients after Resection
المؤلفون المشاركون
Hu, Tsung-Hui
Yen, Yi-Hao
Lin, Chih-Che
Tsai, Meng-Yun
Huang, Pao-Yuan
Sou, Fai-Meng
Cho, Wei-Ru
Wang, Hsin-Ming
Chen, Ding-Wei
Wu, Cheng-Kun
Tsai, Ming-Chao
Chang, Kuo-Chin
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background and Aim.
Liver fibrosis is associated with the prognosis of patients with hepatocellular carcinoma (HCC) after resection.
The fibrosis-4 (FIB-4) index is an accurate and noninvasive marker to determine the degree of liver fibrosis.
Here, we evaluated the effect of pre- and postoperative FIB-4 index in predicting the outcomes after resection of HCC in patients who have chronic hepatitis B (CHB) infection.
Methods.
A total of 534 CHB patients with HCC who received curative hepatectomy between 2001 and 2016 at Kaohsiung Chang Gung Memorial Hospital, Taiwan, were enrolled in this study.
The impact of the FIB-4 index (preoperative and the 1st year after operation) on overall survival (OS) and recurrence-free survival (RFS) was evaluated.
Results.
There was a significant association between the preoperative FIB-4 index and Metavir fibrosis stage (p<0.01).
The multivariate analysis showed that preoperative FIB‐4>2 is an independent risk factor for RFS and OS after HCC curative resection [hazard ratio (HR), 1.902; 95% CI, 1.491–2.460; p<0.001, and HR, 2.207; 95% CI, 1.420–3.429; p<0.001, respectively].
Notably, preoperative FIB-4 is also an independent risk factor for RFS (HR, 1.219; p=0.035) in noncirrhotic patients.
Furthermore, patients had deteriorated FIB-4 1 year after operation [definition: the value the 1st year FIB‐4 after operation minus preoperative FIB‐4>1] and had an adverse outcome in RFS and OS (p<0.001, both).
Conclusion.
The pre and postoperative FIB-4 indexes are useful clinical markers to predict the prognosis in HBV-HCC patients after curative hepatectomy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsai, Meng-Yun& Yen, Yi-Hao& Huang, Pao-Yuan& Sou, Fai-Meng& Lin, Chih-Che& Cho, Wei-Ru…[et al.]. 2019. The Pre- and Postoperative FIB-4 Indexes Are Good Predictors to the Outcomes of HBV-Related HCC Patients after Resection. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1155537
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsai, Meng-Yun…[et al.]. The Pre- and Postoperative FIB-4 Indexes Are Good Predictors to the Outcomes of HBV-Related HCC Patients after Resection. Gastroenterology Research and Practice No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1155537
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsai, Meng-Yun& Yen, Yi-Hao& Huang, Pao-Yuan& Sou, Fai-Meng& Lin, Chih-Che& Cho, Wei-Ru…[et al.]. The Pre- and Postoperative FIB-4 Indexes Are Good Predictors to the Outcomes of HBV-Related HCC Patients after Resection. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1155537
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155537
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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