Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro
المؤلفون المشاركون
Park, Bong-Soo
Kim, In-Ryoung
Kim, Hye-Jin
Yu, Su-Bin
Kang, Hae-Mi
Lee, Ji-Hye
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Bone homeostasis destruction is triggered by the uncontrolled activity of osteoblasts and osteoclasts.
Targeting both the regulation of bone formation and resorption is a promising strategy for treating bone disorders.
Cordycepin is a major component of Chinese caterpillar fungus Cordyceps militaris.
It exerts a variety of biological actions in various cells and animal models.
However, its function on bone metabolism remains unclear.
In the present study, we discovered a dual-action function of cordycepin in murine MC3T3-E1 and RAW264.7 cells.
MC3T3-E1 cells were cultured in an osteogenic medium in the presence of 1 μM cordycepin for up two weeks.
Cordycepin was used for effects of osteoblast and osteoclast differentiation.
Cell viability was measured using the MTT assay.
Osteoblast differentiation was confirmed by alizarin red staining, ALP activity, western blot, and real-time PCR.
Osteoclast differentiation and autophagic activity were confirmed via TRAP staining, pit formation assay, confocal microscopy, western blot, and real-time PCR.
Cordycepin promoted osteoblast differentiation, matrix mineralization, and induction of osteoblast markers via BMP2/Runx2/Osterix pathway.
On the other hand, RAW264.7 cells were differentiated into osteoclast by RANKL treatment for 72 h.
1 μM cordycepin significantly inhibited RANKL-induced osteoclast formation and resorption activity through disturbing the actin ring-formatted sealing zone and activating cathepsin K and MMP9.
These findings indicate that cordycepin might be an innovative dual-action therapeutic agent for bone disease caused by an imbalance of osteoblasts and osteoclasts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Su-Bin& Kim, Hye-Jin& Kang, Hae-Mi& Park, Bong-Soo& Lee, Ji-Hye& Kim, In-Ryoung. 2018. Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155663
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Su-Bin…[et al.]. Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155663
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Su-Bin& Kim, Hye-Jin& Kang, Hae-Mi& Park, Bong-Soo& Lee, Ji-Hye& Kim, In-Ryoung. Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155663
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155663
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر