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Sheng-Jiang Powder Ameliorates High Fat Diet Induced Nonalcoholic Fatty Liver Disease via Inhibiting Activation of AktmTORS6 Pathway in Rats
المؤلفون المشاركون
Wan, Mei-Hua
Tang, Wen-Fu
Zhang, Yumei
Long, Dan
Li, Juan
Zhu, Lv
Kang, Hong-xin
Ren, Hong-yu
Chen, Huan
Miao, Yi-fan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background and Aims.
Nonalcoholic fatty liver disease (NAFLD) is an alarming public health problem that directly contributes to increased prevalence of liver cirrhosis and hepatic cell cancer, but without any specific pharmacological option.
Sheng-jiang powder (SJP), an empirical Chinese medicine formula to treat NAFLD, showed great efficacy but the specific mechanisms have never been reported.
Therefore, we performed this study to explore the effect of SJP on NAFLD and the potential mechanism.
Methods.
NAFLD was induced by high fat diet (HFD) feeding.
Rats were treated with SJP/normal saline daily for 10 weeks and all rats were euthanized after 12 weeks’ feeding.
Liver tissue samples were obtained for biochemistry test and pathological evaluation.
Additionally, oleic acid induced LO2 cells were employed to simulate a cell model of NAFLD.
Cells were subjected to western blotting for Akt, mTOR, S6, SREBP1-c, and FASN detection after coincubated with SJP, LY294002 (a selective PI3K inhibitor), or the combination for 24h.
Results.
HFD significantly induced hepatic steatosis.
Plenty of lipid droplets were observed under transmission electron microscope.
The ultrastructure of liver cells showed distinct changes with obvious endoplasmic reticulum expansion, mitochondrial contraction, and cell matrix solidification.
Although no difference was detected in serum hepatic enzymes and tissue proinflammatory cytokines, the tissue level of SOD and GSH-px was much lower and the pathologic injuries were much severe in HFD feeding rats.
However, SJP treatment significantly attenuated the ultrastructure changes and protected rat liver against inflammatory injury.
Abundant of lipid droplets and high expression of pAkt, pmTOR, pS6, and FASN were observed in oleic acid treated LO2 cells, while these changes were restored by SJP treatment.
Conclusions.
SJP is efficient in attenuating HFD induced NAFLD in rats and this effect might be partly related to the inhibition of Akt/mTOR/S6 pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Juan& Zhu, Lv& Zhang, Yumei& Chen, Huan& Miao, Yi-fan& Kang, Hong-xin…[et al.]. 2018. Sheng-Jiang Powder Ameliorates High Fat Diet Induced Nonalcoholic Fatty Liver Disease via Inhibiting Activation of AktmTORS6 Pathway in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155805
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Juan…[et al.]. Sheng-Jiang Powder Ameliorates High Fat Diet Induced Nonalcoholic Fatty Liver Disease via Inhibiting Activation of AktmTORS6 Pathway in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155805
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Juan& Zhu, Lv& Zhang, Yumei& Chen, Huan& Miao, Yi-fan& Kang, Hong-xin…[et al.]. Sheng-Jiang Powder Ameliorates High Fat Diet Induced Nonalcoholic Fatty Liver Disease via Inhibiting Activation of AktmTORS6 Pathway in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155805
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155805
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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