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Exercise Preconditioning Plays a Protective Role in Exhaustive Rats by Activating the PI3K-Akt Signaling Pathway
المؤلفون المشاركون
Ping, Zheng
Xu, Peng
Zheng, Yu
Li, Jingjing
Cao, Xuebin
Wang, Yang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To investigate whether exercise preconditioning (EP) protects the rat heart from exhaustive exercise- (EE-) induced injury by inducing the PI3K-Akt signaling pathway.
Methods.
84 male Sprague-Dawley rats were randomly divided into 6 groups (n = 14 rats per group): control group (Con), exhaustive exercise group (EE), exercise preconditioning group (EP), exercise preconditioning + exhaustive exercise group (EP + EE), LY294002 (PI3K inhibitor) + exercise preconditioning + exhaustive exercise group (LY + EP + EE), and LY294002 group (LY).
The Con and LY did not exercise.
The remaining groups were subjected to treadmill running.
The structure of myocardial tissue and serum biomarkers of myocardial injury were observed.
Hemodynamic parameters were recorded with a pressure-volume catheter.
TUNEL assay was used to detect the apoptosis of cardiac myocytes, and the level of mitochondrial membrane permeability transforming pore (mPTP) in myocardium was evaluated using ELISA.
Pathway and apoptosis-related proteins in myocardium were assessed using western blotting.
Results.
Compared to the Con group, the EE group showed remarkable myocardial injury, such as cardiac dysfunction and myocardial apoptosis.
Compared to the EE group, the injuries in the EP + EE group were improved.
EP increased the PI3K-Akt signaling pathway and regulated Bcl-2 family to decrease the mPTP openness level.
However, the cardioprotective effects of EP were attenuated when pretreated with the LY294002.
Conclusions.
EP protected the heart from EE-induced injury, and it may improve the cardiac function and reduce the cardiomyocyte apoptosis by activating the PI3K-Akt signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jingjing& Xu, Peng& Wang, Yang& Ping, Zheng& Cao, Xuebin& Zheng, Yu. 2020. Exercise Preconditioning Plays a Protective Role in Exhaustive Rats by Activating the PI3K-Akt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155812
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jingjing…[et al.]. Exercise Preconditioning Plays a Protective Role in Exhaustive Rats by Activating the PI3K-Akt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155812
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jingjing& Xu, Peng& Wang, Yang& Ping, Zheng& Cao, Xuebin& Zheng, Yu. Exercise Preconditioning Plays a Protective Role in Exhaustive Rats by Activating the PI3K-Akt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155812
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155812
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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