6-Gingerol Protects Heart by Suppressing Myocardial IschemiaReperfusion Induced Inflammation via the PI3KAkt-Dependent Mechanism in Rats
المؤلفون المشاركون
Xu, Tongtong
Qin, Guowei
Jiang, Wei
Zhao, Ying
Xu, Yongnan
Lv, Xiangwei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Our previous study has demonstrated that 6-Gingerol (6-G) could alleviate myocardial ischemia/reperfusion injury (MIRI).
However, the molecular mechanism underlying the process of myocardial ischemia/reperfusion (I/R) injury alleviation by 6-G remains unelucidated.
The objective of the present study is to further investigate the potential mechanism for 6-G to alleviate MIRI in rats.
Thirty-two Sprague-Dawley rats were randomly divided into four groups: the Sham group, the I/R group, the 6-G + I/R group, and the LY294002 (LY) + 6-G + I/R group.
For the rats in each of the groups, data were collected for cardiogram, cardiac function, area of myocardial infarction, myocardial pathology, myocardial enzyme, marker of inflammatory response, and PI3K/Akt signaling pathway.
We found that the pretreatment of 6-G with 6 mg/kg could shrink the ST section of cardiogram, improve the cardiac function, reduce the area of myocardial infarction and the degree of cardiac pathological injury, lower the level of myocardial enzyme, and inhibit the inflammatory response.
In addition, our results also indicated that 6-G could upregulate the expression of PI3K and p-Akt and that LY294002, a blocking agent of PI3K/Akt signaling pathway, could nullify the protecting role of 6-G.
Our experimental results showed that 6-G could inhibit I/R-induced inflammatory response through the activation of the PI3K/Akt signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Tongtong& Qin, Guowei& Jiang, Wei& Zhao, Ying& Xu, Yongnan& Lv, Xiangwei. 2018. 6-Gingerol Protects Heart by Suppressing Myocardial IschemiaReperfusion Induced Inflammation via the PI3KAkt-Dependent Mechanism in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155817
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Tongtong…[et al.]. 6-Gingerol Protects Heart by Suppressing Myocardial IschemiaReperfusion Induced Inflammation via the PI3KAkt-Dependent Mechanism in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155817
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Tongtong& Qin, Guowei& Jiang, Wei& Zhao, Ying& Xu, Yongnan& Lv, Xiangwei. 6-Gingerol Protects Heart by Suppressing Myocardial IschemiaReperfusion Induced Inflammation via the PI3KAkt-Dependent Mechanism in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155817
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155817
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر