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Antidiabetic Effects of Arginyl-Fructosyl-Glucose, a Nonsaponin Fraction from Ginseng Processing in Streptozotocin-Induced Type 2 Diabetic Mice through Regulating the PI3KAKTGSK-3β and Bcl-2Bax Signaling Pathways
المؤلفون المشاركون
Liu, Xinglong
Liu, Wencong
Ding, Chuanbo
Zhao, Yingchun
Chen, Xueyan
Khatoon, Sadia
Zheng, Yinan
Cheng, Zhiqiang
Xi, Guangsheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-02
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Streptozotocin- (STZ-) induced type 2 diabetes mellitus (T2DM) caused insulin secretion disorder and hyperglycemia, further causing tissue and organ damage.
In recent years, studies on ginseng (Panax ginseng C.
A.
Meyer) and its saponins (Ginsenosides) have proved to possess antidiabetic pharmacological activities, but the mechanism of nonsaponins on STZ-induced T2DM is still unclear.
Arginyl-fructosyl-glucose (AFG) is a representative nonsaponin component produced in the processing of red ginseng.
The present study was designed to assess the possible healing consequence of AFG on STZ-induced T2DM in mice and also to explore its fundamental molecular contrivances.
T2DM-related indexes, fasting blood glucose levels, and body weight, histological changes, biochemical considerations, biomarkers, the mRNA countenance intensities of inflammatory facts, and variations in correlated protein manifestation in adipose tissue and liver tissue were calculated.
Consequences specified that AFG usage successfully amends STZ-induced insulin conflict and liver grievance in T2DM.
Systematically, AFG action diminished STZ-induced oxidative stress and inflammatory responses in the liver.
In addition, we demonstrated that AFG also attenuates apoptosis and insulin secretion disorders in T2DM by adjusting the PI3K/AKT/GSK3β signaling pathway.
At the end, these discoveries recommend that AFG averts the development of T2DM through numerous types of machinery and proposes that AFG can also be used in order to treat T2DM in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xinglong& Liu, Wencong& Ding, Chuanbo& Zhao, Yingchun& Chen, Xueyan& Khatoon, Sadia…[et al.]. 2020. Antidiabetic Effects of Arginyl-Fructosyl-Glucose, a Nonsaponin Fraction from Ginseng Processing in Streptozotocin-Induced Type 2 Diabetic Mice through Regulating the PI3KAKTGSK-3β and Bcl-2Bax Signaling Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1155893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xinglong…[et al.]. Antidiabetic Effects of Arginyl-Fructosyl-Glucose, a Nonsaponin Fraction from Ginseng Processing in Streptozotocin-Induced Type 2 Diabetic Mice through Regulating the PI3KAKTGSK-3β and Bcl-2Bax Signaling Pathways. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1155893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xinglong& Liu, Wencong& Ding, Chuanbo& Zhao, Yingchun& Chen, Xueyan& Khatoon, Sadia…[et al.]. Antidiabetic Effects of Arginyl-Fructosyl-Glucose, a Nonsaponin Fraction from Ginseng Processing in Streptozotocin-Induced Type 2 Diabetic Mice through Regulating the PI3KAKTGSK-3β and Bcl-2Bax Signaling Pathways. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1155893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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