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The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite-Induced Cataractogenesis in Experimental Animal Models
المؤلفون المشاركون
Azadbakht, Momammad
Asghari, Mohammad
Nowroozpoor Dailami, Kiumars
Davoodi, Ali
Ahmadi, Amirhossein
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Objectives.
Cataract is the leading cause of blindness worldwide.
Although surgery is now considered the most successful cure, the development of alternative treatments is needed due to postsurgical complications.
Oxidative stress in the lens is considered to be the most crucial factor in the formation of cataracts.
Therefore, the effects of the hydroalcoholic extract of Asparagus officinalis L, a traditional antioxidative plant, on cataract formation of sodium selenite were evaluated.
Materials and Methods.
Neonatal rats received a single dose of sodium selenite as an intraperitoneal injection (30 μmol/kg) on day 10 postnatal to induce cataract.
Animals were then posttreated with various oral solutions of A.
officinalis extract at 200 mg/kg or 400 mg/kg once daily on days 10–16 postnatal.
Cataract was evaluated by slit-lamp, and lens opacification was analyzed in each group 24 hours after the last treatment at day seven postadministration of the extracts or vehicle.
The total protein concentration of lenses, glutathione reductase activity as the glutathione antioxidant capacity, and malondialdehyde content as a marker of lipid peroxidation were further assessed in removed rat lenses on day 30 postnatal.
Results.
All lenses in the healthy and control plant groups were clear.
Sodium selenite significantly increased cataract grade (2.8 ± 0.2) when compared to the healthy group p=0.001.
However, cataract grades were decreased considerably as 1.9 ± 0.72 and 1.5 ± 0.85 in groups that received 200 mg/kg and 400 mg/kg oral extract of A.
officinalis, respectively.
A.
officinalis extract also restored all abnormalities of biochemical markers induced by sodium selenite.
Conclusion.
Our data suggest that A.
officinalis could be a promising candidate as a safe alternative treatment in cataracts upon further clinical trials.
This effect is probably associated with the antioxidant activity of A.
officinalis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azadbakht, Momammad& Asghari, Mohammad& Nowroozpoor Dailami, Kiumars& Davoodi, Ali& Ahmadi, Amirhossein. 2020. The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite-Induced Cataractogenesis in Experimental Animal Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azadbakht, Momammad…[et al.]. The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite-Induced Cataractogenesis in Experimental Animal Models. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azadbakht, Momammad& Asghari, Mohammad& Nowroozpoor Dailami, Kiumars& Davoodi, Ali& Ahmadi, Amirhossein. The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite-Induced Cataractogenesis in Experimental Animal Models. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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