Usefulness of a Kampo Medicine on Stress-Induced Delayed Gastric Emptying in Mice
المؤلفون المشاركون
Takayama, Shin
Mogami, Sachiko
Ishii, Tadashi
Fujitsuka, Naoki
Arita, Ryutaro
Nahata, Miwa
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Anxiety and depression often occur with gastrointestinal symptoms.
Although the Japanese traditional medicine (Kampo medicine) bukuryoingohangekobokuto (BGH) is approved for treating anxiety, neurotic gastritis, and heartburn, its effect on gastrointestinal motility remains poorly known.
This study aimed to examine the effect of BGH on delayed gastric emptying in stress model mice and clarified its action mechanism.
Seven-week-old C57BL/6 male mice were acclimated for a week and fasted overnight.
Stress hormone, corticotropin-releasing factor (CRF), was intracerebroventricularly injected to mice, and solid nutrient meal (ground chow and distilled water) was orally administered 1 hour after.
Gastric contents were collected to evaluate gastric emptying rates by measuring its dry weight.
Injection of CRF (0.3 or 1.0 μg/mouse) significantly delayed the 2-hour gastric emptying in mice.
BGH (1.0 g/kg), which was administered 30 minutes before the CRF injection, significantly ameliorated the delayed gastric emptying induced by CRF (0.3 μg/mouse).
BGH (0.5, 1.0 g/kg) significantly enhanced the 1-hour gastric emptying and slightly increased the 2-hour gastric emptying in mice without CRF injection.
In vitro functional assays showed that components of BGH antagonized or inhibited CRF type-2, dopamine D2/D3, neuropeptide Y Y2 receptors, or acetylcholinesterase.
In conclusion, the components of BGH may exert synergistic effects on improving gastric emptying via various targets.
BGH is considered to be potentially useful for treating gastrointestinal dysmotility with psychological symptoms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mogami, Sachiko& Arita, Ryutaro& Nahata, Miwa& Fujitsuka, Naoki& Takayama, Shin& Ishii, Tadashi. 2020. Usefulness of a Kampo Medicine on Stress-Induced Delayed Gastric Emptying in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155924
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mogami, Sachiko…[et al.]. Usefulness of a Kampo Medicine on Stress-Induced Delayed Gastric Emptying in Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155924
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mogami, Sachiko& Arita, Ryutaro& Nahata, Miwa& Fujitsuka, Naoki& Takayama, Shin& Ishii, Tadashi. Usefulness of a Kampo Medicine on Stress-Induced Delayed Gastric Emptying in Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155924
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155924
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر