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Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes
المؤلفون المشاركون
Rossoni Júnior, Joamyr Victor
Chaves, Míriam Martins
Silva, Marcelo Eustáquio
Pedrosa, Maria Lucia
Costa, Daniela Caldeira
Taylor, Jason G.
do Nascimento Kaut, Natália Nogueira
Rabelo, Ana Carolina Silveira
Araujo, Glaucy Rodrigues
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Diabetes mellitus is a metabolic disorder that causes severe complications due to the increased oxidative stress induced by disease.
Many plants are popularly used in the treatment of diabetes, e.g., Baccharis trimera (carqueja).
The aim of this study was to explore the potential application of the B.
trimera hydroethanolic extract in preventing redox stress induced by diabetes and its hypoglycemic properties.
Experiments were conducted with 48 female rats, divided into 6 groups, named C (control), C600 (control + extract 600 mg/kg), C1200 (control + extract 1200 mg/kg), D (diabetic), D600 (diabetic + 600 mg/kg), and D1200 (diabetic + 1200 mg/kg).
Type 1 diabetes was induced with alloxan, and the animals presented hyperglycemia and reduction in insulin and body weight.
After seven days of experimentation, the nontreated diabetic group showed changes in biochemical parameters (urea, triacylglycerol, alanine aminotransferase, and aspartate aminotransferase) and increased carbonyl protein levels.
Regarding the antioxidant enzymes, an increase in superoxide dismutase activity was observed but in comparison a decrease in catalase and glutathione peroxidase activity was noted which suggests that diabetic rats suffered redox stress.
In addition, the mRNA of superoxide dismutase, catalase, and glutathione peroxidase enzymes were altered.
Treatment of diabetic rats with B.
trimera extract resulted in an improved glycemic profile and liver function, decreased oxidative damage, and altered the expression of mRNA of the antioxidants enzymes.
These results together suggest that B.
trimera hydroethanolic extract has a protective effect against diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
do Nascimento Kaut, Natália Nogueira& Rabelo, Ana Carolina Silveira& Araujo, Glaucy Rodrigues& Taylor, Jason G.& Silva, Marcelo Eustáquio& Pedrosa, Maria Lucia…[et al.]. 2018. Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
do Nascimento Kaut, Natália Nogueira…[et al.]. Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1155928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
do Nascimento Kaut, Natália Nogueira& Rabelo, Ana Carolina Silveira& Araujo, Glaucy Rodrigues& Taylor, Jason G.& Silva, Marcelo Eustáquio& Pedrosa, Maria Lucia…[et al.]. Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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