Network Pharmacology Strategy to Investigate the Pharmacological Mechanism of HuangQiXiXin Decoction on Cough Variant Asthma and Evidence-Based Medicine Approach Validation
المؤلفون المشاركون
Xia, Qingqing
Liu, Mingtao
Tian, Lijun
Qi, Jia
Zhang, Yufeng
Li, Hui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-30
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the pharmacological mechanism of HuangQiXiXin decoction (HQXXD) on cough variant asthma (CVA) and validate the clinical curative effect.
Methods.
The active compounds and target genes of HQXXD were searched using TCMSP.
CVA-related target genes were obtained using the GeneCards database.
The active target genes of HQXXD were compared with the CVA-related target genes to identify candidate target genes of HQXXD acting on CVA.
A medicine-compound-target network was constructed using Cytoscape 3.6.0 software, and a protein-protein interaction (PPI) network was constructed using the STRING database.
Gene ontology (GO) function enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed using RGUI3.6.1 and Cytoscape 3.6.0.
We searched the main database for randomized controlled trials of HQXXD for CVA.
We assessed the quality of the included studies using the Cochrane Reviewers’ Handbook.
A meta-analysis of the clinical curative effect of HQXXD for CVA was conducted using the Cochrane Collaboration’s RevMan 5.3 software.
Results.
We screened out 48 active compounds and 217 active target genes of HQXXD from TCMSP.
The 217 active target genes of HQXXD were compared with the 1481 CVA-related target genes, and 132 candidate target genes for HQXXD acting on CVA were identified.
The medicine-compound-target network and PPI network were constructed, and the key compounds and key targets were selected.
GO function enrichment and KEGG pathway enrichment analysis were performed.
Meta-analysis showed that the total effective rate of the clinical curative effect was significantly higher in the experimental group than the control group.
Conclusion.
The pharmacological mechanism of HQXXD acting on CVA has been further determined, and the clinical curative effect of HQXXD on CVA is remarkable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xia, Qingqing& Liu, Mingtao& Li, Hui& Tian, Lijun& Qi, Jia& Zhang, Yufeng. 2020. Network Pharmacology Strategy to Investigate the Pharmacological Mechanism of HuangQiXiXin Decoction on Cough Variant Asthma and Evidence-Based Medicine Approach Validation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1155955
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xia, Qingqing…[et al.]. Network Pharmacology Strategy to Investigate the Pharmacological Mechanism of HuangQiXiXin Decoction on Cough Variant Asthma and Evidence-Based Medicine Approach Validation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1155955
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xia, Qingqing& Liu, Mingtao& Li, Hui& Tian, Lijun& Qi, Jia& Zhang, Yufeng. Network Pharmacology Strategy to Investigate the Pharmacological Mechanism of HuangQiXiXin Decoction on Cough Variant Asthma and Evidence-Based Medicine Approach Validation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1155955
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155955
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر