Abdominal Massage Reduces Visceral Hypersensitivity via Regulating GDNF and PI3KAKT Signal Pathway in a Rat Model of Irritable Bowel Syndrome
المؤلفون المشاركون
Li, Bo
Luo, Xiong-Fei
Liu, Si-Wen
Zhao, Na
Li, Hua-Nan
Zhang, Wei
Chen, Ying-Ying
Bao, An
Wang, Jin-Gui
Wang, Qiang-Song
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Changes in gut motility and visceral hypersensitivity are two major features of irritable bowel syndrome (IBS).
Current drug treatments are often poorly efficacious, with many side effects for patients with IBS.
Complementary therapies, such as acupuncture or abdominal massage, have received more attention in recent years.
In this study, a rat model of IBS with diarrhea (IBS-D) was established by instillation of acetic acid from the colon.
The effects of abdominal massage on changes in gut motility, visceral hypersensitivity, and the possible mechanism were investigated.
Continuous abdominal massage could decrease the stool consistency score and increase the efflux time of glass beads compared with model groups, while also decreasing mast cell counts in IBS-D rats.
The mRNA and protein expressions of neuronal nitric oxide synthase (nNOS), choline acetyl transferase (CHAT), and protein gene product 9.5 (PGP9.5) were significantly upregulated by continuous abdominal massage compared with model groups.
Continuous abdominal massage also improved the ultrastructure of enteric glial cells (EGCs) by decreasing the number of mitochondria and increasing the level of the heterochromatin.
Meanwhile, continuous abdominal massage could upregulate the expression of glial cell line-derived neurotrophic factor (GDNF) and P-Akt/Akt.
Furthermore, it could reduce visceral hypersensitivity and improve the IBS-D symptoms by regulating the phosphoinositide 3-kinase (PI3K)-Akt pathway, which would provide a novel method for the treatment of IBS-D in the clinical setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Bo& Luo, Xiong-Fei& Liu, Si-Wen& Zhao, Na& Li, Hua-Nan& Zhang, Wei…[et al.]. 2020. Abdominal Massage Reduces Visceral Hypersensitivity via Regulating GDNF and PI3KAKT Signal Pathway in a Rat Model of Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Bo…[et al.]. Abdominal Massage Reduces Visceral Hypersensitivity via Regulating GDNF and PI3KAKT Signal Pathway in a Rat Model of Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Bo& Luo, Xiong-Fei& Liu, Si-Wen& Zhao, Na& Li, Hua-Nan& Zhang, Wei…[et al.]. Abdominal Massage Reduces Visceral Hypersensitivity via Regulating GDNF and PI3KAKT Signal Pathway in a Rat Model of Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر