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Efficacy and Safety of Wenxin Granules and Propafenone in Treatment of Atrial Premature Beats: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Yuan, Yi
Li, Duo-duo
Li, Hai-xia
Fu, Jian-ping
Wu, Hong-li
Xiong, Xingjiang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
A meta-analysis was conducted on the clinical efficacy and safety of Wenxin granules and propafenone for the therapy of atrial premature beats (APBs).
Methods.
A randomized controlled trial (RCT) of Wenxin granules and propafenone in the therapy of APB was systematically searched until June 1, 2019.
Meta-analysis was conducted with review manager (RevMan) 5.3.
For the evaluation of methodological quality for randomized controlled trials, the Cochrane tool was used to assess the risk of bias.
For the evaluation of the evidence quality, the online GRADEpro GDT was used.
Results.
Eleven RCTs with 1149 participants were included in this study.
It has been identified that Wenxin granules combined with propafenone have better clinical efficacy than the use of propafenone alone in the treatment of APB (OR = 3.89, 95% CI (2.03, 7.44), P<0.0001, low-dose propafenone; OR = 4.24, 95% CI (1.32, 13.60), P=0.02, high-dose propafenone).
There is no difference in clinical efficacy between the Wenxin granules alone and high-dose propafenone in the treatment of APB (OR = 1.17, 95% CI (0.65, 2.11), P=0.60), and Wenxin granules alone are superior to the low-dose propafenone in the treatment of APB (OR = 2.56, 95% CI (1.34, 4.89), P=0.004).
Wenxin granules combined with propafenone can reduce the incidence of sinus bradycardia caused by propafenone (OR = 0.15, 95% CI (0.03, 0.70), P=0.02).
There was no significant difference between Wenxin granules combined with propafenone and propafenone alone in causing the atrioventricular block, dizziness, xerostomia, gastrointestinal symptoms, and tongue paresthesia.
There was no significant difference between Wenxin granules alone and propafenone alone in causing dizziness, xerostomia, gastrointestinal symptoms, tongue paresthesia, frequent premature ventricular contractions, and prolongation of R-R interval.
Conclusion.
Very low-quality evidence showed that Wenxin granules may be superior to low-dose propafenone in the treatment of APB.
Wenxin granules may reduce the incidence of sinus bradycardia caused by propafenone.
Limited by the quality of included RCTs, the conclusions of this study still need further verification.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Yi& Xiong, Xingjiang& Li, Duo-duo& Li, Hai-xia& Fu, Jian-ping& Wu, Hong-li. 2020. Efficacy and Safety of Wenxin Granules and Propafenone in Treatment of Atrial Premature Beats: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156022
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Yi…[et al.]. Efficacy and Safety of Wenxin Granules and Propafenone in Treatment of Atrial Premature Beats: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1156022
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Yi& Xiong, Xingjiang& Li, Duo-duo& Li, Hai-xia& Fu, Jian-ping& Wu, Hong-li. Efficacy and Safety of Wenxin Granules and Propafenone in Treatment of Atrial Premature Beats: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156022
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156022
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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