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Effect and Mechanism of ShiZhiFang on Uric Acid Metabolism in Hyperuricemic Rats
المؤلفون المشاركون
Ou, Jiao Ying
Wu, Yan Sheng
He, Fei
He, Li Qun
Dong Gao, Jian
Wan, Qiang
Shi, Liqiang
Li, YingQiao
Wang, Huiling
Wang, Yixing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To explore the effect and mechanism of ShiZhiFang on uric acid metabolism.
Methods.
40 rats were divided into normal group, model group, ShiZhiFang group, and benzbromarone group.
The hyperuricemic rat model was induced by yeast gavage at 15 g/kg and potassium oxonate intraperitoneal injection at 600 mg/kg for two weeks.
During the next two weeks, ShiZhiFang group rats were given ShiZhiFang by gavage, and benzbromarone group rats were given benzbromarone by gavage.
The serum uric acid, creatinine, blood urea nitrogen, XOD activity, urinary uric acid, urinary β 2-MG, and histopathological changes were observed in the rats of each group after treatment.
Results.
The hyperuricemic model was established successfully and did not show the increase of serum creatinine and blood urea nitrogen.
Compared with the model group, the serum uric acid, serum XOD activity, and urinary β 2-MG were significantly decreased ( p < 0.05 ), and 24 h urinary uric acid excretion was significantly decreased ( p < 0.0 1 ) in ShiZhiFang group, whereas the two treatment groups were of no statistical significant in above indicators ( p > 0.05 ); renal histopathology showed that the lesions in two treatment groups were reduced compared to the model groups.
The gene and protein expression of uric acid anion transporters rOAT1 and rOAT3 in the kidney was significantly higher than that in model group ( p < 0.01 ).
Conclusion.
The model is suitable for the study of primary hyperuricemia.
The mechanisms of ShiZhiFang on uric acid metabolism in hyperuricemic rats may be involved in reducing the activity of serum XOD and promoting the transcription and expression of rOAT1 and rOAT3 in the kidney.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yan Sheng& Wang, Yixing& Ou, Jiao Ying& Wan, Qiang& Shi, Liqiang& Li, YingQiao…[et al.]. 2018. Effect and Mechanism of ShiZhiFang on Uric Acid Metabolism in Hyperuricemic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156045
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yan Sheng…[et al.]. Effect and Mechanism of ShiZhiFang on Uric Acid Metabolism in Hyperuricemic Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156045
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yan Sheng& Wang, Yixing& Ou, Jiao Ying& Wan, Qiang& Shi, Liqiang& Li, YingQiao…[et al.]. Effect and Mechanism of ShiZhiFang on Uric Acid Metabolism in Hyperuricemic Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156045
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156045
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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