Osteomeles schwerinae Extract Prevents Diabetes-Induced Renal Injury in Spontaneously Diabetic Torii Rats
المؤلفون المشاركون
Kim, Chan-Sik
Jo, Kyuhyung
Sohn, Eun Jin
Kim, Jin Sook
Kim, Junghyun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Mesangial cell proliferation contributes to the development of glomerulosclerosis in diabetic nephropathy.
This study was aimed at determining whether Osteomeles schwerinae (OSSC) extract can ameliorate renal damage in Spontaneously Diabetic Torii (SDT) rats.
OSSC extract (100 and 250 mg/kg/day) was administered to the SDT rats through oral gavage for 17 weeks.
At the end of the experiment, glucose, HbA1c, and albuminuria were measured.
In addition, the levels of mesangial proliferation-related proteins were determined by western blotting and immunohistochemistry.
Our results show that albuminuria, accumulation of the extracellular matrix (ECM), and renal expansion were markedly restored by OSSC extract administration.
The OSSC treatment also inhibited α-smooth muscle actin and transforming growth factor-β1 protein expression.
In addition, OSSC and its bioactive compounds hyperoside and quercitrin inhibited the platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor-B receptor (PDGFR-β) ligand binding in an in vitro assay.
Taken together, these results indicate that OSSC inhibits ECM accumulation and mesangial proliferation of the glomeruli in SDT rats through inhibition of the interaction between PDGF-BB and PDGFR-β.
OSSC has ameliorating effects on the initiation and progression of diabetes complications and can be used for the treatment of early diabetic renal dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sohn, Eun Jin& Kim, Junghyun& Kim, Chan-Sik& Jo, Kyuhyung& Kim, Jin Sook. 2018. Osteomeles schwerinae Extract Prevents Diabetes-Induced Renal Injury in Spontaneously Diabetic Torii Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156047
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sohn, Eun Jin…[et al.]. Osteomeles schwerinae Extract Prevents Diabetes-Induced Renal Injury in Spontaneously Diabetic Torii Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156047
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sohn, Eun Jin& Kim, Junghyun& Kim, Chan-Sik& Jo, Kyuhyung& Kim, Jin Sook. Osteomeles schwerinae Extract Prevents Diabetes-Induced Renal Injury in Spontaneously Diabetic Torii Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156047
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156047
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر